Recent Updates
Recently added Catalysts

Delayed and mesalazine

Phase 3

Colitis, Ulcerative | Small molecule | Gastrointestinal |Takeda Pharmaceutical Company Limited|Last Updated: Jun 11, 2021

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment280

FDA Designations

No designations recorded

Clinical trial landscape

Delayed and mesalazine · 1 trial · 1 indication

Phase 3 1
NCT00503243Safety and Efficacy of SPD476 (Mesalazine) Given Twice Daily (2.4 g/Day) vs SPD476 Given as a Single Dose (4.8 g/Day) in Subjects With Acute Mild to Moderate Ulcerative ColitisColitis, Ulcerative
COMPLETED280 Analytics
PHASE3COMPLETED
Safety and Efficacy of SPD476 (Mesalazine) Given Twice Daily (2.4 g/Day) vs SPD476 Given as a Single Dose (4.8 g/Day) in Subjects With Acute Mild to Moderate Ulcerative Colitis
Colitis, UlcerativeUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of subjects in remission (Ulcerative Colitis Disease Activity Index score of <= 1, with scores of 0 for rectal bleeding and stool frequency, and a sigmoidoscopy score reduction of 1 point or more from baseline
8 weeks

Secondary Endpoints

Clinical improvement as defined by a drop of => 3 points from baseline in the overall UC-DAI score
8 weeks
Change in the UC-DAI score
8 weeks
Change in symptoms (rectal bleeding and stool frequency)
2, 4 and 8 weeks
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
Delayed and extended release mesalazineDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * newly diagnosed or diagnosis of relapsing (relapsed \<= 6 weeks to baseline) mild to moderate ulcerative colitis * women not of childbearing potential or WOCP who agreed to use an effective contraceptive method Exclusion Criteria: * severe ulcerative colitis or relapsed for ...

Countries:United States
Unlock Eligibility Criteria

Frequently asked questions about Delayed and mesalazine

What is Delayed and mesalazine used for?

Delayed and mesalazine is an investigational small molecule being studied for the treatment of ulcerative colitis, a form of inflammatory bowel disease. It is in Phase 3 clinical development for this gastrointestinal condition. The drug is being evaluated in patients with acute mild to moderate ulcerative colitis.

Who makes Delayed and mesalazine?

Delayed and mesalazine is being developed by Takeda Pharmaceutical Company Limited, which trades under the ticker TAK. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with ulcerative colitis.

What phase is Delayed and mesalazine in?

Delayed and mesalazine is in Phase 3 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still undergoing clinical trials to assess its safety and effectiveness for treating ulcerative colitis.

What clinical trials is Delayed and mesalazine in?

Delayed and mesalazine has one completed Phase 3 clinical trial, identified as NCT00503243. This study evaluated the safety and efficacy of the drug given twice daily at 2.4 g/day versus a single dose of 4.8 g/day in 280 subjects with acute mild to moderate ulcerative colitis in the United States.

Is Delayed and mesalazine the same as mesalazine?

Delayed and mesalazine is a formulation of mesalazine, also known as 5-aminosalicylic acid. The drug is being developed as a delayed-release oral formulation for the treatment of ulcerative colitis, and the clinical trial evaluates different dosing regimens of this mesalazine product.