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Cyclobenzaprine

Phase 3

Neck Pain | Small molecule | Musculoskeletal |Takeda Pharmaceutical Company Limited|Last Updated: Apr 8, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment180
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02814565Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local OriginPHASE3 COMPLETED 180Oct 12, 2016Mar 14, 2017Apr 8, 201910 Russia
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Study Endpoints
Primary Endpoints
Percentage of Participants With Subject's Rating of Medication Helpfulness Impression on Day 3 of Treatment
Day 3

Participants assessed the study medication helpfulness on a daily basis (in the daily diary), using the following 5-point rating scale: "How would you rate this study medication in improving your condition?" "0 = poor", "1 = fair", "2 = good", "3 = very good", "4 = excellent".

Secondary Endpoints
Percentage of Participants With Subject's Rating of Medication Helpfulness Impression on Days 7 and 14 of Treatment
Days 7 and 14
Percentage of Participants With Physician's Clinical Global Assessment on Day 3 of Treatment
Day 3
Percentage of Participants With Physician's Clinical Global Assessment on Days 7 and 15 of Treatment
Days 7 and 15
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Cyclobenzaprine HCl 15 mgEXPERIMENTALCyclobenzaprine Hydrochloride (HCl) extended-release, 15 mg capsules, orally, once daily for 14 days.
PlaceboPLACEBO_COMPARATORCyclobenzaprine HCl extended release placebo-matching capsules, orally, once daily for 14 days.
Interventions
NameTypeDescription
Cyclobenzaprine HClDRUGCyclobenzaprine HCl extended-release capsules
PlaceboDRUGCyclobenzaprine HCl extended release placebo-matching capsules
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Eligibility Criteria
Age Range18 Years — 50 Years
SexALL
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: 1. In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements. 2. Signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures. 3. Is experien...

Countries:Russia
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