Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Calcitriol · 1 trial · 1 indication
This shows the effect that lanthanum carbonate or sevelamer carbonate has on the pharmacokinetics of oral calcitriol. Exogenous calcitriol was the difference between total calcitriol value and the baseline exogenous calcitriol value at each sampling timepoint.
| Arm | Type | Description |
|---|---|---|
| Calcitriol | ACTIVE_COMPARATOR | - |
| Lanthanum carbonate + calcitriol | EXPERIMENTAL | - |
| Sevelamer carbonate + calcitriol | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| Calcitriol | DRUG | Calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period. |
| Lanthanum carbonate + Calcitriol | DRUG | Lanthanum carbonate (1000 mg three times daily with meals for one day) + calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period. |
| Sevelamer carbonate + Calcitriol | DRUG | Sevelamer carbonate (2400 mg three times daily with meals for one day) + calcitriol (1.0 microgram) single dose at lunch administered on Day 1 of the study period. |
Inclusion criteria * Healthy volunteers age 19-45 years inclusive at the time of consent. * Satisfactory medical assessment with no clinically significant or relevant abnormalities in medical history, physical examination, vital signs, electrocardiogram (ECG) and laboratory evaluation (hematology, ...
Calcitriol is a small molecule being studied in healthy volunteers. It is the active form of vitamin D and is being investigated for its pharmacokinetics when administered alone or in combination with other drugs. The drug is currently in Phase 1 clinical development.
Calcitriol is being developed by Takeda Pharmaceutical Company Limited, which trades under the ticker TAK. The company is conducting clinical trials to study the drug's pharmacokinetics in healthy volunteers.
Calcitriol is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The drug is being studied in healthy volunteers to assess its pharmacokinetics.
Calcitriol has one completed Phase 1 clinical trial, NCT00925704, which studied the pharmacokinetics of Rocaltrol when administered alone or in combination with Fosrenol or Renvela in healthy volunteers. The trial enrolled 41 participants in the United States.
Yes, Calcitriol is also known as Rocaltrol. The clinical trial NCT00925704 specifically studied the pharmacokinetics of Rocaltrol, which is the brand name for Calcitriol, when given alone or with other medications.