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SPY002-091

Phase 1

Healthy | Small molecule | Other |Spyre Therapeutics, Inc.|Last Updated: Aug 17, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment56
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06672718A Study of SPY002-091 in Healthy VolunteersPHASE1 RECRUITING 56Nov 26, 2024Jun 22, 2026Aug 17, 20251 United States
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Study Endpoints
Primary Endpoints
Treatment emergent adverse events
Up to 40 weeks

Incidence, severity, and causal relationship of TEAEs

Secondary Endpoints
Cmax
Up to 40 weeks
Tmax
Up to 40 weeks
AUC
Up to 40 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
SAD Cohorts, Experimental ArmEXPERIMENTALParticipants will receive a single dose of SPY002-091 in a dose escalation format
SAD Cohorts, Placebo ArmPLACEBO_COMPARATORParticipants will receive a single dose of placebo
Interventions
NameTypeDescription
SPY002-091DRUGExperimental
PlaceboOTHERPlacebo
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy men and women * Willing and able to attend the necessary visits to the CRU, comply with all testing requirements, remain at the study site unit for the duration of the confinement period and return for the outpatient visits Exclusion Criteria: * Participation in more...

Countries:United States
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06672718primaryCompletionDate: changed
LOWMay 24, 2026NCT06672718studyFirstPostDate: changed