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Simpliciti Shoulder System

Phase 3

Primary Generalized (Osteo)Arthritis | Unknown | Musculoskeletal |Stryker Corporation|Last Updated: Apr 25, 2023

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment157
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01390038Simpliciti IDE Trial; Replacing the Humeral Head in Total Shoulder ArthroplastyPHASE3 COMPLETED 157Jul 1, 2011Dec 1, 2014Apr 25, 202314 United States
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Study Endpoints
Primary Endpoints
Device Success Rate
24 months

A subject is a Patient Success at 24-months if: 1. There is NO continuous radiolucent line around the prosthesis; and 2. The adjusted Constant Score is \> 85 (successful outcome); and 3. They did not have revision surgery; and 4. They did not have a system-related serious adverse event.

Secondary Endpoints
Quality of Life
24 months
Range of Motion
24 months
Strength
24 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Simpliciti™ Shoulder SystemEXPERIMENTALThe Simpliciti™ Shoulder System is intended for Total Shoulder Arthroplasty of the shoulder.
Interventions
NameTypeDescription
Simpliciti™ Shoulder SystemDEVICETotal shoulder arthroplasty system
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Eligibility Criteria
Age Range22 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites14

Inclusion Criteria: * Adult subject 22 years or older * Clinical indication for total shoulder replacement due to primary diagnosis of arthritis. Primary arthritis for this study includes osteoarthritis, and/or traumatic arthritis. * Scapula and proximal humerus must have reached skeletal maturity ...

Countries:United States
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