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FDA decisions, readouts and PDUFA dates · scored by probability of approval
| Catalyst | Drug / Treatment | Stage | Prob. of Approval | Description | Drug Type | Therapeutic Area | Source |
|---|
Dated clinical, regulatory and corporate events for Synlogic, Inc.
How SYBX actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| No matching catalysts | ||||||
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SYNB1618 Small moleculeCompletedNCT03516487 | Phenylketonuria | Phase 2 | COMPLETED | 90 | Jun 21, 2019 | ||||||
| SYNB1934 Small moleculeCompletedNCT04984525 | Phenylketonuria | Phase 1 | COMPLETED | 106 | Dec 10, 2021 | ||||||
| SYNB8802v1 Small moleculeCompletedNCT05377112 | Enteric Hyperoxaluria | Phase 1 | COMPLETED | 11 | Dec 7, 2022 | ||||||
| SYNB8802 Small moleculeCompletedNCT04629170 | Enteric Hyperoxaluria | Phase 1 | COMPLETED | 77 | Jan 17, 2023 | ||||||
| SYNB1353 Small moleculeCompletedNCT05462132 | Homocystinuria | Phase 1 | COMPLETED | 31 | Nov 27, 2022 |
Readouts, endpoints and source filings for every SYBX program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| SYNB8802 | Enteric Hyperoxaluria | Phase 1b | 2022-12-15 | -38% reduction in urinary oxalate compared to placebo; -28% (-37.2, -18.2) change from baseline in urinary oxalate vs. placebo at the 1x1011 TID dose; -38% (-46.4, -28.7) change from baseline in urinary oxalate vs. placebo at the 3x1011 TID doseRead More | Synlogic Announces Achievement of Proof of Concept for SYNB8802 in Enteric Hyperoxaluria Based on Urinary Oxalate Lowering in Phase 1b Study Results include -38% reduction in urinary oxalate compared to placebo in Roux-eRead More |
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| New Enterprise Associates 14, L.P.10% Owner | BuyWarrant exercise | 2,640,845 2,640,845 held | $0.00 | 07/27/2026 |
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| NEA Management Company, LLC | 0.2 % (-33.3 %) | 3.27 M | 2.92 M |
Shares sold short, counted twice a month.
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
How SYBX ranks across every disease it competes in