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Two doses of commercial scale inactivated SARS-CoV-2 vaccine at the schedule of day 0, 14

Phase 3

Covid19 | Monoclonal antibody | Infectious Disease |Sinovac Biotech, Ltd|Last Updated: Jul 27, 2021

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLEDDMC
Total Trials1
Total Enrollment1,040

FDA Designations

No designations recorded

Clinical trial landscape

Two doses of commercial scale inactivated SARS-CoV-2 vaccine at the schedule of day 0, 14 · 1 trial · 1 indication

Phase 3 1
NCT04617483Study of the Commercial Scale SARS-CoV-2 Vaccine Against the Pilot Scale Among Adults, and Bridging Study of the Immunogenicity in Elderly Against That in AdultsCovid19
COMPLETED1,040 Analytics
PHASE3COMPLETED
Study of the Commercial Scale SARS-CoV-2 Vaccine Against the Pilot Scale Among Adults, and Bridging Study of the Immunogenicity in Elderly Against That in Adults
Covid19Unlock trial analytics

Study Endpoints

Primary Endpoints

Immunogenicity index-geometric mean titer(GMT) of neutralizing antibody
Day 14 after the full course vaccination

Neutralizing antibody assay will be performed using the micro-neutralization method

Secondary Endpoints

Immunogenicity index-Seroconversion rate of the neutralizing antibody
Day 14 after the full course vaccination
Immunogenicity index-Seropositive rate of the neutralizing antibody
Day 14 after the full course vaccination
Safety index-Incidence of adverse reactions
From the beginning of the vaccination to 28 days after the full course vaccination
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Aged 26-45, Commercial ScaleEXPERIMENTALCommercial scale inactivated SARS-CoV-2 vaccine in adults aged 26-45 years.
Aged 18-59, Pilot ScaleEXPERIMENTALPilot scale inactivated SARS-CoV-2 vaccine in adults aged 18-59 years.
Aged ≥60, Pilot ScaleEXPERIMENTALPilot scale inactivated SARS-CoV-2 vaccine in elderly aged above 60 years.

Interventions

NameTypeDescription
Two doses of commercial scale inactivated SARS-CoV-2 vaccine at the schedule of day 0,14BIOLOGICALThe antigen content of the commercial scale inactivated SARS-CoV-2 vaccine was 600SU/0.5ml, vaccinated in the age group 26-45.
Two doses of pilot scale inactivated SARS-CoV-2 vaccine at the schedule of day 0,14BIOLOGICALThe antigen content of the pilot scale inactivated SARS-CoV-2 vaccine was 600SU/0.5ml, vaccinated in the age group 18-59.
Two doses of pilot scale inactivated SARS-CoV-2 vaccine at the schedule of day 0,14 in elderlyBIOLOGICALThe antigen content of the pilot scale inactivated SARS-CoV-2 vaccine was 600SU/0.5ml, vaccinated in the age group above 60.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Healthy adults aged 18-59 or elderly aged ≥60 years; 2. Proven legal identity. Exclusion Criteria: 1. Travel/residence history of communities with reported cases within 14 days before trial; 2. History of exposure to Novel Coronavirus infection (nucleic acid positive) withi...

Countries:China
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