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Rabies vaccine

Phase 3

Rabies (Healthy Volunteers) | Monoclonal antibody | Other |Sinovac Biotech, Ltd|Last Updated: Jul 9, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment390
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07055893Immunogenicity and Safety of Rabies Vaccine (Serum-free Vero Cell) in a Simulated Post-exposure Prophylaxis RegimenPHASE3 NOT YET_RECRUITING 390Mar 1, 2026Jan 30, 2027Jul 9, 20251 Pakistan
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Study Endpoints
Primary Endpoints
Proportion of participants achieving a rabies virus neutralizing antibody (RVNA) titer ≥0.5 IU/mL
Day 14 and Day 28 after the first dose vaccination
Secondary Endpoints
Geometric mean concentrations (GMCs) of RVNA titers
Day 14, Day 28 and Day 42 after the first dose vaccination
Proportion of participants achieving a RVNA titer ≥0.5 IU/mL
Day 42 after the first dose vaccination
Incidence of adverse reactions
Up to 28 days after the last-dose vaccination
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Sinovac rabies vaccineEXPERIMENTALParticipants will be randomly assigned to receive Sinovac rabies vaccine.
Sanofi Pasteur Verorab®ACTIVE_COMPARATORParticipants will be randomly assigned to receive the marketed rabies vaccine Verorab®
Interventions
NameTypeDescription
Rabies vaccineBIOLOGICALReceiving five doses of rabies vaccine manufactured by Sinovac using the "Essen" PEP schedule
Verorab®BIOLOGICALReceiving five doses of marketed rabies vaccine manufactured by Sanofi using the "Essen" PEP schedule
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Eligibility Criteria
Age Range1 Year — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Populations aged ≥1 years old; 2. Participants and/or participants' parents/legal guardians are able to understand and sign the informed consent form (ICF) voluntarily; 3. Participants are able to comply with the study procedures based on the investigator's assessment; 4. In ...

Countries:Pakistan
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07055893primaryCompletionDate: changed
LOWMay 24, 2026NCT07055893studyFirstPostDate: changed