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PROVARIX

Phase 3

Varicella (Chickenpox) | Monoclonal antibody | Infectious Disease |Sinovac Biotech, Ltd|Last Updated: Mar 16, 2026

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials1
Total Enrollment300

FDA Designations

No designations recorded

Clinical trial landscape

PROVARIX · 1 trial · 2 indications

Phase 3 1
NCT07475000Second Dose of Varicella Vaccine in Healthy ChildrenVaricella (Chickenpox)
RECRUITING300 Analytics
PHASE3RECRUITING
Second Dose of Varicella Vaccine in Healthy Children
Varicella (Chickenpox)Unlock trial analytics

Study Endpoints

Primary Endpoints

Geometric Mean Concentration (GMC) of Varicella-Zoster Virus (VZV) Antibodies
42 days after vaccination (Day 42)
Geometric Mean Fold Rise (GMFR) of Varicella-Zoster Virus (VZV) Antibodies
42 days after vaccination (Day 42)

Secondary Endpoints

Seropositive Rate of Varicella-Zoster Virus (VZV) Antibodies
42 days after vaccination (Day 42)
Seroresponse Rate of Varicella-Zoster Virus (VZV) Antibodies
42 days after vaccination (Day 42)
Incidence of Adverse Reactions Within 42 Days After Vaccination
Day 0 to Day 42 after vaccination
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
Group 1EXPERIMENTALThe first dose administered was VARIVAX(varicella vaccine manufactured by Merck)
Group 2EXPERIMENTALThe first dose administered was VARILRIX(varicella vaccine manufactured by GSK)
Group 3EXPERIMENTALThe first dose administered was SUDUVAX(varicella vaccine manufactured by GC Biopharma)
Group 4EXPERIMENTALThe first dose administered was SKYVaricella(varicella vaccine manufactured by SK bioscience)
Group 5EXPERIMENTALThe first dose administered was PROVARIX(varicella vaccine manufactured by Sinovac)

Interventions

NameTypeDescription
PROVARIXBIOLOGICALParticipants will receive one dose (0.5 mL) of PROVARIX (VarV), a live attenuated varicella vaccine manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd., administered as the second dose of varicella vaccination.
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Eligibility Criteria

Age Range15 Months to 12 Years
SexALL
Healthy VolunteersYes
Study Sites5

Inclusion Criteria: 1. Healthy children aged 15 months to 12 years. 2. Have received one dose of varicella vaccine at 12 months of age in Turkey (verified by vaccination card or official electronic immunization record). 3. Written informed consent obtained from parent(s) or legally authorized repre...

Countries:Turkey (Türkiye)
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Frequently asked questions about PROVARIX

What is PROVARIX used for?

PROVARIX is a monoclonal antibody being developed for varicella, commonly known as chickenpox. It is intended for use in healthy children as part of a vaccination strategy, specifically as a second dose of varicella vaccine. The drug is currently in Phase 3 clinical development.

Who makes PROVARIX?

PROVARIX is being developed by Sinovac Biotech, Ltd, a biopharmaceutical company traded under the ticker SVA. The company is conducting a Phase 3 clinical trial for this varicella vaccine candidate in healthy children.

What phase is PROVARIX in?

PROVARIX is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The ongoing Phase 3 trial is recruiting participants to evaluate the second dose of the varicella vaccine in healthy children.

What clinical trials is PROVARIX in?

PROVARIX is being studied in a Phase 3 clinical trial with the identifier NCT07475000, titled 'Second Dose of Varicella Vaccine in Healthy Children.' The trial is currently recruiting 300 participants in Turkey (Türkiye) and includes children aged 15 months and older.

Is PROVARIX the same as a varicella vaccine?

PROVARIX is a varicella vaccine candidate, not a therapeutic monoclonal antibody. It is being developed to prevent chickenpox and is being tested as a second dose in healthy children. The drug is in Phase 3 trials and is not yet approved.