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Investigational live attenuated mumps vaccine

Phase 3

Mumps | Monoclonal antibody | Other |Sinovac Biotech, Ltd|Last Updated: Oct 1, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment1,140
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05065177Safety and Immunogenicity Study of Live Attenuated Mumps Vaccines in Healthy InfantsPHASE3 COMPLETED 1,140Jan 1, 2016Apr 1, 2016Oct 1, 20211 China
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Study Endpoints
Primary Endpoints
The seroconversion rates (SCRs) of susceptible subjects in each group
28 days

Subjects whose pre-immune HI antibody level \< 1:2 are considered susceptible; among these subjects, those with post-immune HI antibody level ≥ 1:2 are considered seroconverted.

Secondary Endpoints
The incidences of adverse events (AEs) of each group
28 days
The incidences of serious adverse events (SAEs) of each group
28 days
The post-immune geometric mean titers (GMTs) of susceptible subjects in each group
28 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Experimental GroupEXPERIMENTAL* Single intramuscular injection of the investigational vaccine (0.5 ml) on Day 0; * Intervention: investigational live attenuated mumps vaccine;
Control GroupACTIVE_COMPARATOR* Single intramuscular injection of the control vaccine (0.5 ml) on Day 0; * Intervention: control live attenuated mumps vaccine;
Interventions
NameTypeDescription
Investigational live attenuated mumps vaccineBIOLOGICALThe investigational vaccine was manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd.
control live attenuated mumps vaccineBIOLOGICALThe control vaccine was manufactured by Zhejiang VACN bio-pharmaceutical Co. Ltd.
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Eligibility Criteria
Age Range8 Months — 18 Months
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy volunteer between 8 - 18 months old; * Proven legal identity; * Guardian(s) of the volunteer should be capable of understanding the written consent form, and such form should be signed before the infant being included into this study; * Complying with the requirement o...

Countries:China
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