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SPN-804O

Phase 1

Epilepsies, Partial | Small molecule | Other |Supernus Pharmaceuticals, Inc.|Last Updated: Jul 2, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDBiomarker
Total Trials1
Total Enrollment18
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00918047Study of PK and Safety of OXC (Oxcarbazepine) XR (Extended Release) as Adjunctive Therapy in Pediatric Epilepsy PatientsPHASE1 COMPLETED 18Jun 1, 2009Nov 1, 2010Jul 2, 20178 United States
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Study Endpoints
Primary Endpoints
Examine the steady-state pharmacokinetics (PK) of OXC XR and to assess the safety and tolerability of repeated oral dosing of OXC XR in pediatric subjects with partial seizures.
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
SPN-804O 150mg/DayEXPERIMENTALSubjects who weighed 15.0 to 29.9 kg dosed with SPN-804O 150mg/Day
SPN-8040 300mg/DayEXPERIMENTALSubjects who weighed 30.0 to 44.9 kg dosed with SPN-8040 300mg/Day
SPN-8040 450mg/DayEXPERIMENTALSubjects who weighed 45.0 to 59.9 kg dosed with SPN-8040 450mg/Day
SPN-8040 600mg/DayEXPERIMENTALSubjects who weighed 60.0 kg and above dosed with SPN-8040 600mg/Day
Interventions
NameTypeDescription
SPN-804ODRUGOpen Label study
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Eligibility Criteria
Age Range4 Years — 17 Years
SexALL
Healthy VolunteersNo
Study Sites8

Inclusion Criteria: 1. Able to provide written informed assent (IAF), as appropriate, with written informed permission (and informed consent (ICF) where required by regional laws or regulations) from the parent or legally-authorized representative (LAR). 2. Male or female aged 4 to 17 years, inclus...

Countries:United States
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