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Molindone

Phase 2

Impulsive Aggression Comorbid With ADHD in Children | Small molecule | Psychiatry |Supernus Pharmaceuticals, Inc.|Last Updated: May 2, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment78
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01416064Open-Label, Extension Study to 810P202PHASE2 COMPLETED 78Sep 1, 2011Feb 1, 2013May 2, 201728 United States
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Study Endpoints
Primary Endpoints
Long Term Safety and tolerability of repeated oral dosing of 810M as an adjunctive therapy in children exhibiting impulsive aggression comorbid w/ ADHD
over 6 months

Safety Assessments include: Adverse Events, clinical lab tests, vital signs, physical examinations, ECGs, Simpson-Angus Scale, Barnes Akathisia Scale, Abnormal Involuntary Movement Scale (AIMS) and Columbia Suicise Severity Rating Scale (C-SSRS)

Secondary Endpoints
Assess the efficacy of 810M
over 6 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MolindoneOTHERExtension study, all subjects will be given Molindone at different (established) dosage levels based on the patient's weight, response and investigator discretion.
Interventions
NameTypeDescription
MolindoneDRUGThe populations will be comprised of male and female pediatric subjects from the 810P202 study. Subject will be converted to a total daily dose of 18 or 36mg of molindone (depending on weight), following enrollment into 810P203. The dosage level may be adjusted at the investigators discretion.
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Eligibility Criteria
Age Range6 Years — 12 Years
SexALL
Healthy VolunteersNo
Study Sites28

Inclusion Criteria: 1. Successful completion of the 810P202 study. 2. Continues to be medically healthy and with clinically normal laboratory profiles, vital signs, and electrocardiograms (ECGs). 3. Weight of at least 20kg. 4. Able and willing to swallow tablets whole and not chewed, cut or crushed...

Countries:United States
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