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tiotropium pMDI

Phase 1

Healthy | Small molecule | Other |Solventum Corporation|Last Updated: Dec 2, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment46
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03155204Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With A Reference ProductEARLY_PHASE1 COMPLETED 46Apr 25, 2017Mar 19, 2018Dec 2, 20241 United Kingdom
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Study Endpoints
Primary Endpoints
Peak Plasma Concentration (Cmax)
24 hr

noncompartmental analysis

Secondary Endpoints
Adverse events
24 hr
Area Under the Plasma Concentration vs Time Curve (AUC)
24 hr
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Test Product 1EXPERIMENTALtiotropium pMDI 2 inhalations
Test Product 2EXPERIMENTALtiotropium pMDI 2 inhalations
Test Product 3EXPERIMENTALtiotropium pMDI 2 inhalations
Test Product 4EXPERIMENTALtiotropium pMDI 2 inhalations
Commercial ProductACTIVE_COMPARATORtiotropium Respimat 2 inhalations
Interventions
NameTypeDescription
tiotropium pMDIDRUGinhalation
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy Volunteer * Willing and able to give informed consent * Willing to withhold all alcoholic beverages for 48 hours and all xanthine- containing foods and beverages for 24 hours prior to reporting to clinic * Subjects must agree to use an adequate method of contraception ...

Countries:United Kingdom
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