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3M CHG/IPA Prep

Phase 2

Surgical Skin Preparation | Small molecule | Dermatology |Solventum Corporation|Last Updated: Oct 2, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment28
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03681990In Vivo Preoperative Skin Preparation Efficacy Study Within a Defined Product Coverage AreaPHASE2 COMPLETED 28Jun 6, 2017Jul 4, 2017Oct 2, 20241 Romania
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Study Endpoints
Primary Endpoints
Comparison of Log Change of Skin Flora Relative to Pre-treatment (Baseline) in Each of 3 Sampling Sites at a Defined Post-treatment Sampling Time.
Post-treatment sampling randomized as 10-minute or 13-minute post-product application

The primary measure of efficacy is change in skin flora log10 CFU/cm\^2 in each of the skin sampling sites relative to baseline skin flora log10 CFU/cm\^2. Baseline samples must satisfy the greater than or equal to 3.0 in each of the sampling sites, to be used for data analysis.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
3M CHG/IPA Prep / CenterEXPERIMENTALChlorhexidine gluconate (CHG) 2% / Isopropyl alcohol (IPA) 70% solution applied topically to intact skin; sample collected from center test site on skin in application area.
3M CHG/IPA Prep / Mid-peripheralEXPERIMENTALChlorhexidine gluconate (CHG) 2% / Isopropyl alcohol (IPA) 70% solution applied topically to intact skin; sample collected from mid-peripheral test site on skin in application area.
3M CHG/IPA Prep / PeripheralEXPERIMENTALChlorhexidine gluconate (CHG) 2% / Isopropyl alcohol (IPA) 70% solution applied topically to intact skin; sample collected from peripheral test site on skin in application area.
Interventions
NameTypeDescription
3M CHG/IPA PrepDRUGApply topically to intact skin
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male subjects of any race who are at least 18 years of age, * Subjects must have an area on their back region to accommodate the treatment coverage area, * Subjects must be in good general health, * Subjects who satisfy all inclusion/exclusion criteria and will voluntarily rea...

Countries:Romania
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