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somatropin

Phase 3

Fetal Growth Retardation | Small molecule | Other |Sanofi|Last Updated: Oct 5, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment306
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00452491MAXOMAT ® in the Treatment of Severe Early Onset Intrauterine Growth Retardation on Pre-pubertal ChildrenPHASE3 COMPLETED 306May 1, 1993Apr 1, 2010Oct 5, 20101 France
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Study Endpoints
Primary Endpoints
Efficacy data : measurement of height
at trimestrial visit
Secondary Endpoints
laboratory test assessment and evaluation of bone age
at every other visit
measurement of anti-GH and anti-ECP antibodies
one visit out of four
Tolerance data : undesirable events
throughout the study
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
somatropinDRUG0.2 IU/kg/day 7 days per week given sequentially (alternating periods of 6 months of treatment and 6 months of no treatment) for 3 years
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Eligibility Criteria
Age Range3 Years — 11 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Pre-pubertal children of either sex presenting with severe early onset intrauterine growth retardation (I.U.G.R.) * Height Less Than or Equal to -3 SD Exclusion Criteria: * Age less than 3 years The above information is not intended to contain all considerations relevant to...

Countries:France
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