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ferroquine

Phase 1

Malaria | Small molecule | Infectious Disease |Sanofi|Last Updated: Dec 21, 2009

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment72

FDA Designations

No designations recorded

Clinical trial landscape

ferroquine · 1 trial · 1 indication

Phase 1 1
NCT00563914A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated MalariaMalaria
COMPLETED72 Analytics
PHASE1COMPLETED
A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria
MalariaUnlock trial analytics

Study Endpoints

Primary Endpoints

Hepatic safety :ALT, AST, Alkaline Phosphatase, Total Bilirubin
Sreening , baseline, days D3,D5,D6,D7,D9,D14,D21 and D28

Secondary Endpoints

Parasite clearance assessed by repeated measurements of parasitemia
Sreening, days D1(T6 and T12),D2 (T0 and T6), D3( T0, T6 and T12) ,D4,D7,D14,D21and D28
Pharmacokinetics of ferroquine assessed by repeated measurement of blood concentration
up to 28 days after last dosing
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -

Interventions

NameTypeDescription
ferroquine (SSR97193)DRUGassociated with artesunate
amodiaquineDRUGassociated with artesunate
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Eligibility Criteria

Age Range18 Years to 65 Years
SexMALE
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Body weight between 50 kg and 90 kg with Body Mass Index \>18 kg/m² * Presence of body temperature ≥ 37.5°C or history of fever within the last 24 hours * Monoinfection with Plasmodium falciparum and parasitemia within the 100 to 200,000/microL Exclusion Criteria: * Hypersen...

Countries:GabonKenya
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Competitive Landscape -Malaria 6 trials

Frequently asked questions about ferroquine

What is ferroquine used for?

Ferroquine is an investigational small molecule being developed for the treatment of malaria. It has been studied in African adult patients with uncomplicated malaria. The drug is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes ferroquine?

Ferroquine is being developed by Sanofi, a pharmaceutical company listed on the stock exchange under the ticker symbol SNY. The company is conducting clinical research to evaluate the safety and activity of ferroquine in patients with malaria.

What phase is ferroquine in?

Ferroquine is currently in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved for use outside of clinical trials. One Phase 1 study has been completed to assess its safety and activity in patients with uncomplicated malaria.

What clinical trials is ferroquine in?

Ferroquine has been studied in one completed clinical trial with the identifier NCT00563914. This Phase 1 study compared ferroquine combined with artesunate versus amodiaquine combined with artesunate in African adult patients with uncomplicated malaria. The trial enrolled 72 male participants in Gabon and Kenya.

How does ferroquine work?

Ferroquine is a small molecule that acts as an antimalarial agent. It is being studied in combination with artesunate for the treatment of uncomplicated malaria. The drug is designed to target the malaria parasite, though its specific molecular target has not been disclosed.

Is ferroquine the same as amodiaquine?

No, ferroquine is not the same as amodiaquine. Ferroquine is a distinct investigational drug being developed by Sanofi. In clinical trials, ferroquine combined with artesunate was compared against amodiaquine combined with artesunate to evaluate their relative safety and activity in patients with malaria.