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Yellow fever vaccine

Phase 3

Yellow Fever | Monoclonal antibody | Other |Sanofi|Last Updated: Feb 3, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment254
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07222059Phase 3 Single Arm, Open Study on vYF in AdultsPHASE3 COMPLETED 254Oct 23, 2025Dec 25, 2025Feb 3, 20264 Japan
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Study Endpoints
Primary Endpoints
Percentage of participants with seroconversion to YF virus in YF-naive participants
28 days after one dose of vYF vaccine

Seroconversion rates will be assessed using a YF MN assay Seroconversion is defined as a 4-fold increase in neutralizing Ab (NAb) titers as compared to the pre-vaccination value (Day 01)

Secondary Endpoints
Percentage of participants with seroprotection to YF virus
At Day 01 and Day 29
Percentage of participants with seroconversion to YF virus
28 days after one dose of vYF vaccine
Geometric Mean Titers (GMTs) of neutralizing antibodies against YF virus
At Day 01 and Day 29
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
vYFEXPERIMENTALOne single dose of vYF will be administered subcutaneously at the 1st visit
Interventions
NameTypeDescription
Yellow fever vaccine (live)BIOLOGICALPharmaceutical form:Powder and diluent for suspension for injection-Route of administration:Subcutaneous
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites4

Inclusion Criteria: * Aged from 18 years on the day of inclusion\* \* "From 18 years" means from the day of the 18th birthday * Participants who are healthy as determined by medical evaluation including medical history and physical examination. * Able to attend all scheduled visits and to comply...

Countries:Japan
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