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Tdap

Phase 2

Pregnant Women | Monoclonal antibody | Other |Sanofi|Last Updated: Aug 27, 2020

Success Probability

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Trial Design

RandomizedDouble-BlindACTIVE_CONTROLLEDDMC
Total Trials1
Total Enrollment320

FDA Designations

No designations recorded

Clinical trial landscape

Tdap · 1 trial · 1 indication

Phase 2 1
NCT00553228Pertussis Maternal Immunization StudyPregnant Women
COMPLETED320 Analytics
PHASE2COMPLETED
Pertussis Maternal Immunization Study
Pregnant WomenUnlock trial analytics

Study Endpoints

Primary Endpoints

Comparison of serum IgG antibody levels against PT, FHA, PRN, FIM between Tdap and Td groups
birth, 2, 4, 6, 7, 12, and 13 months of age

Secondary Endpoints

Safety of Tdap in pregnancy including pregnancy outcome and developmental assessment.
developmental screening at 1 year of age
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION

Treatment Arms

ArmTypeDescription
group IEXPERIMENTALTdap
group 2ACTIVE_COMPARATORTd

Interventions

NameTypeDescription
TdapBIOLOGICAL0.5 mL IM once at visit #2
TdBIOLOGICAL0.5 mL IM once at visit #2
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Eligibility Criteria

Age Range18 Years to N/A
SexFEMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Pregnant women 18 years of age and over. * Women who, at ≥30-\<32 weeks gestation, are at low risk for complications as determined by the obstetrical algorithm for identification of eligible subjects and the obstetrical risk assessment form. * Signed, informed consent. Exclus...

Countries:Canada
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Frequently asked questions about Tdap

What is Tdap used for in pregnant women?

Tdap is an investigational vaccine being studied for use in pregnant women to prevent pertussis, also known as whooping cough. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities. The vaccine is being evaluated for its safety and effectiveness in this population.

Who makes Tdap?

Tdap is being developed by Sanofi, a multinational pharmaceutical company listed on the stock exchange under the ticker symbol SNY. Sanofi is conducting clinical trials to evaluate the vaccine's use in pregnant women for the prevention of pertussis.

What phase is Tdap in?

Tdap is currently in Phase 2 clinical development. It is an investigational vaccine and has not yet received regulatory approval. The Phase 2 trial, which has been completed, was designed to assess the vaccine's safety and immunogenicity in pregnant women.

What clinical trials is Tdap in?

Tdap has been studied in one clinical trial with the identifier NCT00553228, titled 'Pertussis Maternal Immunization Study.' This Phase 2 trial was completed and enrolled 320 healthy female participants aged 18 years and older in Canada. The study was randomized, double-blind, and active-controlled.

Is Tdap the same as a pertussis vaccine?

Tdap is a vaccine being studied for the prevention of pertussis, commonly known as whooping cough. It is specifically being evaluated for maternal immunization, meaning it is given to pregnant women to potentially protect their infants from the disease. The vaccine is still investigational and not yet approved.