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SR57746A

Phase 3

Metastases | Small molecule | Oncology |Sanofi|Last Updated: Sep 13, 2006

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment620

FDA Designations

No designations recorded

Clinical trial landscape

SR57746A · 1 trial · 3 indications

Phase 3 1
NCT00272051XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV ChemotherapyMetastases
COMPLETED620 Analytics
PHASE3COMPLETED
XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy
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Study Endpoints

Primary Endpoints

Clinical evaluation of peripheral sensory neuropathy using the Oxaliplatin specific scale for dose adjustment : Q2W ; response rate using RECIST criteria : Q8W

Secondary Endpoints

Safety : Q2W ; Nerve conduction studies : Baseline + cycle 12 ; Progression Free Survival : Q8W ; Survival
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION

Interventions

NameTypeDescription
SR57746ADRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Histologically or cytologically proven adenocarcinoma of the colon or the rectum * age \> 18 years * WHO performance status : 0,1,2 * Signed written informed consent prior to study entry * Disease stage : metastatic disease not amenable to potentially curative treatment (eg : ...

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Frequently asked questions about SR57746A

What is SR57746A used for?

SR57746A, also known as xaliproden, is an investigational small molecule being studied for its potential to reduce neurotoxicity in patients with metastatic colorectal cancer receiving oxaliplatin plus 5-FU/LV chemotherapy. It is in Phase 3 clinical development for this oncology indication.

What does SR57746A target?

SR57746A is a small molecule developed by Sanofi. Its specific molecular target has not been disclosed in available clinical trial information. The drug is being evaluated for its ability to reduce chemotherapy-induced neurotoxicity in patients with metastatic colorectal cancer.

Who makes SR57746A?

SR57746A is being developed by Sanofi, a global biopharmaceutical company listed on the stock exchange under the ticker SNY. The drug is currently in Phase 3 clinical development for reducing neurotoxicity associated with oxaliplatin-based chemotherapy in metastatic colorectal cancer.

What phase is SR57746A in?

SR57746A is in Phase 3 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 3 trial has been completed to evaluate its efficacy in reducing neurotoxicity in patients with metastatic colorectal cancer receiving oxaliplatin plus 5-FU/LV chemotherapy.

What clinical trials is SR57746A in?

SR57746A has been studied in one completed Phase 3 clinical trial, identified as NCT00272051. This trial, titled XENOX, evaluated the efficacy of xaliproden in reducing the neurotoxicity of oxaliplatin plus 5-FU/LV chemotherapy in 620 patients with metastatic colorectal cancer.

Is SR57746A the same as xaliproden?

Yes, SR57746A is also known as xaliproden. The drug is being developed by Sanofi and has been investigated in a Phase 3 clinical trial for reducing neurotoxicity in patients with metastatic colorectal cancer receiving oxaliplatin-based chemotherapy.