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SAR444336

Phase 2

Microscopic Colitis | Small molecule | Other |Sanofi|Last Updated: Feb 24, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment54
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07156175A Study to Investigate the Efficacy and Safety of SAR444336 in Adults With Microscopic Colitis in Clinical RemissionPHASE2 RECRUITING 54Oct 14, 2025May 6, 2027Feb 24, 202626 Belgium, Denmark +7
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Study Endpoints
Primary Endpoints
Proportion of participants with sustained steroid-free clinical remission
up to week 24

Clinical remission defined as no relapse during the 24-week period.

Secondary Endpoints
Incidence of treatment-emergent adverse events (TEAEs), serious adverse events (SAEs) and adverse events of special interest (AESIs)
up to week 28
Incidence of study investigational medicinal product (IMP) permanent discontinuations and study withdrawals due to treatment-emergent adverse events (TEAEs)
up to week 28
Plasma concentrations of SAR444336
through week 24
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
SAR444336EXPERIMENTALEach participant will receive several injections of SAR444336. Budesonide will be taken at the dose administered by the physician.
PlaceboPLACEBO_COMPARATOREach participant will receive several injections of placebo. Budesonide will be taken at the dose administered by the physician.
Interventions
NameTypeDescription
SAR444336DRUGPharmaceutical form:Solution for injection -Route of administration:Subcutaneous
PlaceboDRUGPharmaceutical form:Solution for injection -Route of administration:Subcutaneous
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites26

Inclusion Criteria: * Participants with histologically confirmed diagnosis of microscopic colitis (including all histological sub-types). * Receiving budesonide therapy. * Documented clinical remission from 2 weeks before screening. * At least 1 microscopic colitis relapse in the last 8 months prio...

Countries:BelgiumDenmarkFranceGermanyHungaryItalyPolandSwedenUnited Kingdom
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07156175primaryCompletionDate: changed
LOWMay 24, 2026NCT07156175studyFirstPostDate: changed