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SAR407899

Phase 2

Erectile Dysfunction | Small molecule | Other |Sanofi|Last Updated: May 2, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00914277SAR407899 Single-dose in Treatment of Mild to Moderate Erectile DysfunctionPHASE2 COMPLETED 24May 1, 2009Oct 1, 2009May 2, 20111 France
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Study Endpoints
Primary Endpoints
Duration of penile rigidity during sexual stimulation
4 hours following drug administration
Secondary Endpoints
Time to onset of penile rigidity
4 hours following drug administration
Blood pressure
12 hours following drug administration
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Sequence 1EXPERIMENTALPeriod 1: placebo Period 2: sildenafil Period 3: SAR407899 dose level 2 Period 4: SAR407899 dose level 1
Sequence 2EXPERIMENTALPeriod 1: sildenafil Period 2: SAR407899 dose level 1 Period 3: placebo Period 4: SAR407899 dose level 2
Sequence 3EXPERIMENTALPeriod 1: SAR407899 dose level 1 Period 2: SAR407899 dose level 2 Period 3: sildenafil Period 4: placebo
Sequence 4EXPERIMENTALPeriod 1: SAR407899 dose level 2 Period 2: placebo Period 3: SAR407899 dose level 1 Period 4: sildenafil
Interventions
NameTypeDescription
SAR407899DRUGOral administration
PlaceboDRUGOral administration
SildenafilDRUGOral administration
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Eligibility Criteria
Age Range18 Years — 60 Years
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * male with mild to moderate erectile dysfunction for at least 6 months * written informed consent Exclusion Criteria: * diabetes mellitus * orthostatic hypotension * hypogonadal testosterone level The above information is not intended to contain all considerations relevant t...

Countries:France
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