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Pentacel: DTaP-IPV/Hib

Phase 3

Diphtheria | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Jan 31, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment1,941
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00662870Study of the Safety, Immunogenicity and Lot Comparability of DAPTACEL When Administered With Other Recommended VaccinePHASE3 COMPLETED 1,941May 1, 2001Jan 1, 2004Jan 31, 201226 United States
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Study Endpoints
Primary Endpoints
Immunogenicity: To provide information concerning the immune response of DAPTACEL after vaccination.
30 days post-vaccination 3
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
DAPTACEL Lot 1EXPERIMENTALParticipants receiving Diphtheria and Tetanus Toxoids and Acellular Pertussis vaccine (DAPTACEL) Lot 1
DAPTACEL Lot 2EXPERIMENTALParticipants receiving Diphtheria and Tetanus Toxoids and Acellular Pertussis vaccine (DAPTACEL) Lot 2
DAPTACEL Lot 3EXPERIMENTALParticipants receiving Diphtheria and Tetanus Toxoids and Acellular Pertussis vaccine (DAPTACEL) Lot 3
PentacelACTIVE_COMPARATORParticipants receiving Pentacel vaccine
Interventions
NameTypeDescription
DAPTACEL® (Diphtheria and Tetanus Toxoids and Acellular Pertussis vaccine)BIOLOGICAL0.5 mL, Intramuscular
Pentacel: DTaP-IPV/HibBIOLOGICAL0.5 mL, Intramuscular
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Eligibility Criteria
Age Range42 Days — 84 Days
SexALL
Healthy VolunteersYes
Study Sites26

Inclusion Criteria : * Healthy infants 2 months of age. * Infants with at least 37 weeks of gestation at delivery. * Signed informed consent from parent or guardian. * Able to attend the scheduled visits and to comply with the study procedure. * Subjects must have received the first dose of hepatit...

Countries:United States
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