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PEDIACEL and Prevenar

Phase 3

Diphtheria | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Jun 3, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment588
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00343421Study to Compare Pediacel® to Infanrix®-IPV+Hib When Both Are Co-Administered With Prevenar® in Infants and ToddlersPHASE3 COMPLETED 588Jul 1, 2006Jun 1, 2009Jun 3, 20162 France, Poland
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Study Endpoints
Primary Endpoints
To provide information concerning the immunogenicity of PEDIACEL® and Infanrix®-IPV+Hib
1 month post-vaccination
Secondary Endpoints
To provide information concerning the safety after administration of PEDIACEL® and Infanrix®-IPV+Hib
Entire study
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Group 1EXPERIMENTALPEDIACEL co-administered with Prevenar
Group 2ACTIVE_COMPARATORInfanrix-IPV+Hib co-administered with Prevenar
Interventions
NameTypeDescription
PEDIACEL® and Prevenar®BIOLOGICAL0.5 mL each, IM (opposite thigh)
Infanrix®-IPV+Hib and Prevenar®BIOLOGICAL0.5 mL each, IM (opposite thigh)
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Eligibility Criteria
Age Range55 Days — 75 Days
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Infants 55 to 75 days old, inclusive on the day of first vaccination * Born at full term of pregnancy (\> 37 weeks) * Informed consent form signed by the parent(s) or the legal guardian * Parents or the legal guardian able to read and write in the local language * Parent(s) or...

Countries:FrancePoland
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