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Insulin human/Insuman Comb 25

Phase 3

Type 2 Diabetes Mellitus | Small molecule | Metabolic |Sanofi|Last Updated: Feb 27, 2013

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment485

FDA Designations

No designations recorded

Clinical trial landscape

Insulin human/Insuman Comb 25 · 1 trial · 1 indication

Phase 3 1
NCT01353469Assessment of Efficacy and Safety of Insuman Comb 25 Versus Novolin® 30R Twice Daily Over 24 Weeks in Type 2 Diabetes Patients With Insulin TherapyType 2 Diabetes Mellitus
COMPLETED485 Analytics
PHASE3COMPLETED
Assessment of Efficacy and Safety of Insuman Comb 25 Versus Novolin® 30R Twice Daily Over 24 Weeks in Type 2 Diabetes Patients With Insulin Therapy
Type 2 Diabetes MellitusUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in HbA1c from baseline to the end of treatment
24 weeks

Secondary Endpoints

Change in fasting plasma glucose from baseline to the end of treatment
24 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Insuman Comb 25EXPERIMENTALInsuman Comb 25 will be self-injected subcutaneously twice daily 30-45 minutes before breakfast and dinner. The dose will be adjusted individually by monitoring the blood glucose values and symptoms, and following China guideline.
Novolin® 30RACTIVE_COMPARATORNovolin® 30R will be self-injected subcutaneously twice daily within 30 minutes before breakfast and dinner. The dose will be adjusted individually by monitoring the blood glucose values and symptoms, and following China guideline and the package insert of Novolin® 30R

Interventions

NameTypeDescription
Insulin human/Insuman Comb 25 (HR1799)DRUGPharmaceutical form:Suspension Route of administration: Subcutaneous
Insulin human/Novolin® 30RDRUGPharmaceutical form:Suspension Route of administration: Subcutaneous
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites23

Inclusion criteria: * Type 2 diabetes mellitus patients, as defined by World Health Organization (WHO), diagnosed for at least 1 year at the time of screening visit who are under premix insulin therapy, with or without oral anti-diabetic drug (OAD) * Signed written informed consent Exclusion crite...

Countries:China
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