Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Hydrochlorothiazide · 1 trial · 1 indication
Sotagliflozin without HCTZ: AUC to the end of the dosing period (AUCtau)
| Arm | Type | Description |
|---|---|---|
| Sotagliflozin + Hydrochlorothiazide (HCTZ) | EXPERIMENTAL | Sotagliflozin to be administered alone in Period 1. HCTZ to be given in Period 2 for 4 days followed immediately by HCTZ and sotagliflozin for 5 days. |
| Name | Type | Description |
|---|---|---|
| Sotagliflozin (SAR439954) | DRUG | Pharmaceutical form: Tablet Route of administration: Oral |
| Hydrochlorothiazide | DRUG | Pharmaceutical form: Tablet Route of administration: Oral |
Inclusion criteria : * Male or female subjects, between 18 and 55 years of age, inclusive. * Body weight between 50.0 and 100.0 kg, inclusive, if male, and between 40.0 and 90.0 kg, inclusive, if female, body mass index between 18.0 and 30.0 kg/m2, inclusive. * Certified as healthy by a comprehensi...