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Hexaxim

Phase 3

Diphtheria | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Apr 5, 2022

Target and mechanism

ModalityMonoclonal antibody

Also known as Hexaxim Vaccine

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment354

FDA Designations

No designations recorded

Clinical trial landscape

Hexaxim · 1 trial · 6 indications

Phase 3 1
NCT02428491Immunogenicity and Safety of Sanofi Pasteur's Combined Vaccine Given as a Three-Dose Primary Series at 2, 3,4 Months of Age and Followed by a Booster Dose Given at 16 to 17 Months of Age in Vietnamese Infants Who Previously Received a Dose of Hepatitis B Vaccine at Birth or Within 1 Week After BirthDiphtheria
COMPLETED354 Analytics
PHASE3COMPLETED
Immunogenicity and Safety of Sanofi Pasteur's Combined Vaccine Given as a Three-Dose Primary Series at 2, 3,4 Months of Age and Followed by a Booster Dose Given at 16 to 17 Months of Age in Vietnamese Infants Who Previously Received a Dose of Hepatitis B Vaccine at Birth or Within 1 Week After Birth
DiphtheriaUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants Reporting Solicited Injection Site Reactions or Solicited Systemic Reactions
Within 7 days after vaccination

Solicited injection site reactions: tenderness, erythema, and swelling (and extensive limb swelling for booster dose). Solicited systemic reactions: fever, vomiting, crying abnormal, drowsiness, appetite loss, and irritability

Secondary Endpoints

Number of Subjects With Seroprotection/Seroconversion/Vaccine Response After Infant Series in Cohort 1
Day 90 (1 month after third dose)
Number of Subjects With Seroprotection/Seroconversion/Vaccine and Booster Response Before and After Booster Vaccination in Cohort 1
Day 425 (pre-booster) and Day 455 (1 month after booster dose)
Geometric Mean Titers or Geometric Mean Concentrations of DTaP-IPV-HB-PRP~T Antibodies Before and After Infant Series in Cohort
Day 90 (1 month after third dose)
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION

Treatment Arms

ArmTypeDescription
DTaP-IPV-HB-PRP~T VaccineEXPERIMENTALAll participants will receive 3 doses of 0.5 mL DTaP-IPV-HB-PRP\~T combined vaccine, intramuscularly, at 2, 3 and 4 months of age (primary series), followed by a booster dose approximately 12 months after the completion of the primary series (at 16 to 17 months of age).

Interventions

NameTypeDescription
Hexaxim®BIOLOGICALDTaP-IPV-Hep B-PRP-T combined vaccine, 0.5 mL, Intramuscular
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Eligibility Criteria

Age Range61 Days to 91 Days
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Aged 61 to 91 days on the day of the first study visit * Born at full term of pregnancy (≥ 37 weeks) and with a birth weight ≥2.5 kg * Informed consent form has been signed and dated by the parent(s) or other legally acceptable representative (and by an independent witness if ...

Countries:Vietnam
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Frequently asked questions about Hexaxim

What is Hexaxim used for?

Hexaxim is a vaccine used for the prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infections. It is administered as a three-dose primary series at 2, 3, and 4 months of age, followed by a booster dose at 16 to 17 months of age.

Who makes Hexaxim?

Hexaxim is developed by Sanofi, a company listed on the stock exchange under the ticker symbol SNY. The vaccine is being studied for use in infants to protect against multiple infectious diseases.

What phase is Hexaxim in?

Hexaxim is in Phase 3 clinical development. It is an investigational vaccine and has not yet been approved by regulatory authorities. A Phase 3 clinical trial has been completed to evaluate its immunogenicity and safety.

What clinical trials is Hexaxim in?

Hexaxim has been studied in one completed Phase 3 clinical trial, identified as NCT02428491. This trial enrolled 354 participants in Vietnam and evaluated the vaccine's immunogenicity and safety when given as a three-dose primary series followed by a booster dose in infants.

Is Hexaxim the same as Hexaxim Vaccine?

Yes, Hexaxim is also known as Hexaxim Vaccine. Both names refer to the same vaccine product developed by Sanofi for the prevention of diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b infections.

What does Hexaxim target?

Hexaxim is a vaccine that targets multiple pathogens, including those causing diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and Haemophilus influenzae type b. It works by stimulating the immune system to produce protection against these infectious diseases.