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HBVAXPRO 5µg

Phase 3

Virus Diseases | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Sep 11, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment751
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02012998Study of the Immunogenicity and Safety of a Challenge Dose of HBVAXPRO in Healthy Children Vaccinated 10 Years Ago With 3 Doses of HEXAVAC or INFANRIX HEXAPHASE3 COMPLETED 751Jan 1, 2014Feb 1, 2015Sep 11, 201710 Italy
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Study Endpoints
Primary Endpoints
Percentage of subjects with an anti-hepatitis B concentration ≥10 mIU/mL
One month after the challenge dose
Secondary Endpoints
Percentage of subjects with an anti-hepatitis B concentration ≥10 mIU/mL
Prior to challenge dose (At Day 0 prior to administration of the challenge dose)
Solicited injection-site adverse reactions and pyrexia
Day 0 to day 4 after vaccination
Unsolicited injection-site adverse reactions and systemic adverse events
Day 0 to day 14 after vaccination
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
HBVAXPRO Challenge doseEXPERIMENTALHBVAXPRO 5µg
Interventions
NameTypeDescription
HBVAXPRO 5µgBIOLOGICAL0.5mL intramuscular injection
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Eligibility Criteria
Age Range10 Years — 12 Years
SexALL
Healthy VolunteersYes
Study Sites10

Inclusion Criteria: * Healthy child * Child vaccinated with 3 doses of HEXAVAC or 3 doses of INFANRIX HEXA as infant * Child vaccinated with the third dose of HEXAVAC or INFANRIX HEXA at least 10 years prior to challenge dose Exclusion Criteria: * Receipt of more than 3 doses of any Hepatitis B c...

Countries:Italy
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