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SBSenti Biosciences Holdings, Inc.

$0.97

+0.04 (+4.12%)

D 23Pipeline Score Richly Valued Biotech · Clinical
Market Cap
30.74 M
EPS
-1.92
P/E Ratio
-
Value Trade
146.23 K
SEC Financials
Q1 2026
  • Dilution Risk

    60%
  • Revenue

    16.00 K

  • R&D Expenses

    5.28 M

  • Operating CF

    -7.48 M


  • Total Assets

    38.24 M

  • Total Liabilities

    35.68 M

  • Equity

    2.56 M

  • D/E Ratio

    12,345

-6.9 %
Week
-14.18 %
1 Month
9.66 %
3 Month
-45.48 %
6 Month
-99.01 %
5 Year
-99.01 %
All Time
Cash Data
Caution
  • Cash Position

    18.75 M

  • Monthly Burn

    2.49 M

  • Runway

    6.6 mo

  • Burn Trend

    Decelerating
  • SEC Filing

    May 14, 2026
Overview
Volume
28.92 K
52 Week Range
0.77 - 3.88
% held by Insiders
0 %
% held by Institutions
10.92 %
Enterprise Value
40.94 M
Total Shares
26.26 M
Short %
5.63 %
Float Shares
10.11 M
Company Description
HQ: 2 CORPORATE DRIVE, FIRST FLOOR...
Employees:39

locked

Upcoming Catalyst
Catalyst Drug/Treatment Stage Probability of Approval Description Drug Type Therapeutic Area Source
Example Drug Treatment for example condition requiring FDA review
Phase 3
-%
Small Molecule
Oncology
Example Drug Treatment for example condition requiring FDA review
Phase 3
-%
Small Molecule
Oncology
Example Drug Treatment for example condition requiring FDA review
Phase 3
-%
Small Molecule
Oncology
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Drug Pipeline Intelligence
D23
Pipeline Score
$2M
Pipeline Value
Richly Valued
Valuation Signal
2
Drugs Scored
0.1x
rNPV / MCap
Top 22%
Micro Cap
(rank 707 of 905)
Percentile Rank
Senti Biosciences Holdings, Inc. faces pipeline headwinds (23/100), with $177M risk-adjusted pipeline value, led by SENTI-202 in AML/MDS (Phase 1).
Showing 1 of 1 assets
DrugIndicationPhaseNCT IDPTRSrNPVStatusEnrollmentVelocityDesignCompletionML SignalLast Change
SENTI-202
Monoclonal antibody
AML/MDSPhase 1NCT0632574826% $106M ACTIVE NOT_RECRUITING 21 SLOW D (27) Aug 1, 2040MODERATE_RISKLOW
May 26, 2026
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Inside Trades
TREND
CORPORATE INSIDERS BOUGHT SHARES WORTH 1.8M IN THE LAST 3 MONTHS
YEARLY INSIDER TRANSACTIONS
Sector Avg.
INSIDERS
SOLD
INSIDERS
BOUGHT
POSITIVE SENTIMENT Based on 22 Insiders Transactions
Unlock Inside Trades data
Hedge Funds
TREND
HEDGE FUNDS INCREASED HOLDINGS BY 200.0K SHARES IN THE LAST QUARTER
Shares Held
2040.00B1530.00B1020.00B510.00B0
Q3
2024
Q4
2024
Q1
2025
Q2
2025
HEDGE FUNDS
SOLD
HEDGE FUNDS
BOUGHT
POSITIVE SENTIMENT Based on 27 hedge funds in the last quarter
18 buying (3 new)·9 selling (1 exited)·2 unchanged
Fund Count
60%
Share Volume
25%
Conviction
15%
HedgeFund Name
( 3 )
% of Portfolio Current MV
-
Shares Owned
-
Activity
Avg Price $0

Example Capital Management

2.5 %
15.00 M
250.00 K

Example Capital Management

2.5 %
15.00 M
250.00 K

Example Capital Management

2.5 %
15.00 M
250.00 K
Unlock Hedge Funds table data
Biotech Analyst Ratings
Symbol
Firm
Rating
Action
Price Target
Upside
date
SNTI
Example Securities
Buy
Initiated
$150.00
+25%
2026-01-15
SNTI
Example Securities
Buy
Initiated
$150.00
+25%
2026-01-15
SNTI
Example Securities
Buy
Initiated
$150.00
+25%
2026-01-15
Unlock Biotech Analyst Ratings data
SNTI Stock Forecast & Analyst Consensus
BUY
Analyst Ratings
Buy65.0%
Hold25.0%
Sell10.0%
Price Target Trend
Average$24.00
Low$18.00
High$32.00
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SNTI Institutional Ownership Trends
Current Insider %
5.20%
+0.00%
Current Institutional %
62.40%
+0.00%
Total Ownership
67.60%
Insider + Institutional
Data Points
1
1 Ticker(s)
Option Chain Statistics
ExpirationVolumeOpen InterestImplied Volatility CallsImplied Volatility Puts
CallsPutsPut-Call RatioCallsPutsPut-Call RatioIVOiWaIvVWaIvIVOiWaIvVWaIv
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Option Chain
CallsStrikePuts
Last PriceVolumeOpen InterestLast PriceVolumeOpen Interest
No data available
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Unlock Options Chart data
Open interest
0 600K 1.2M 1.8M Avg OI 1.00 M Open Interest
0 1 2 3 1.1 Put-Call Ratio
Today's Open Interest
1.00 M
Put-Call Ratio
1.1
Put Open Interest
480.00 K
Call Open Interest
520.00 K
Open Interest Avg (30-day)
900,000
Today vs Open Interest Avg (30-day)
11.11%
Option Volume
0 450K 900K 1.4M Avg OV 750.00 K Option Volume
0 1 2 3 0.95 Put-Call Ratio
Today's Volume
750.00 K
Put-Call Ratio
0.95
Put Volume
360.00 K
Call Volume
390.00 K
Volume Avg (30-day)
800,000
Today vs Volume Avg (30-day)
-6.25%
Company News
-SNTI
Apr 14, 2026
SNTIConferences/Events

Senti Biosciences to Present on Logic-Gated Cell Therapies in Educational Session at AACR Annual Meeting 2026

Senti Biosciences will present its innovative Logic-Gated cell therapies at the AACR Annual Meeting 2026. CEO Timothy Lu will discuss the advancements of the SENTI-202 therapy, which selectively targets cancer cells while protecting healthy ones. The session aims to highlight the potential of Logic Gates in oncology, particularly for relapsed/refractory acute myeloid leukemia.

Read more →
-SNTI
Apr 1, 2026
SNTIGeneral

Senti Biosciences Announces Publication in Cell Systems Demonstrating Advanced Logic-Gated CAR Design for Cell Therapies

Senti Biosciences has published new research in Cell Systems showcasing its innovative NOT-gated CAR circuits, which enhance the precision and safety of cell therapies. The study indicates that these circuits can improve the efficacy of immune cells in targeting tumors while sparing healthy tissue. This research supports Senti's ongoing development of its Gene Circuit platform for cancer treatments.

Read more →
-SNTI
Mar 27, 2026
SNTIGeneral

Senti Bio Reports Fourth Quarter and Full Year 2025 Financial Results and Provides a Corporate Update

Senti Biosciences reported its financial results for Q4 and full year 2025, highlighting significant progress in its clinical pipeline, particularly with SENTI-202 for relapsed/refractory AML. The company received RMAT designation from the FDA and reported positive preliminary clinical data. However, it also faced a substantial net loss for the year.

Read more →
-SNTI
Mar 23, 2026
SNTIConferences/Events

Senti Biosciences to Present Clinical and Translational Data on SENTI-202 at the 11th Annual Innate Killer Conference

Senti Biosciences is set to present clinical and translational data for its SENTI-202 program at the 11th Annual Innate Killer Conference. The Phase I trial focuses on a novel CAR NK cell therapy targeting CD33 and FLT3 in adults with relapsed/refractory acute myeloid leukemia. Presentations will highlight both clinical results and the therapy's unique mechanism of action.

Read more →
-SNTI
Mar 3, 2026
SNTIConferences/Events

Senti Biosciences to Present at Leerink Partners 2026 Global Healthcare Conference

Senti Biosciences, a clinical-stage biotechnology company, announced that CEO Timothy Lu will present at the Leerink Partners 2026 Global Healthcare Conference in Miami on March 9, 2026. The company focuses on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform, which aims to enhance precision in targeting cancer cells. A webcast of the presentation will be available on their website.

Read more →
-SNTI
Feb 24, 2026
SNTIConferences/Events

Senti Biosciences to Present at TD Cowen 46th Annual Health Care Conference

Senti Biosciences, a clinical-stage biotech firm, will present at the TD Cowen 46th Annual Health Care Conference on March 2, 2026. CEO Timothy Lu will discuss the company's Gene Circuit technology, pipeline advancements, and partnership opportunities. The event will be available via live webcast, emphasizing Senti's commitment to developing innovative therapies for incurable diseases.

Read more →
-SNTI
Feb 20, 2026
SNTIConferences/Events

Senti Bio Participates in Cell & Gene Live Event Highlighting Cutting-Edge Technologies Advancing Cell Therapy Development

Senti Biosciences participated in the Cell & Gene Live event, discussing advancements in cell therapy development. The company highlighted its Gene Circuit platform and its product candidate, SENTI-202, designed to target hematologic malignancies. SENTI-202 has received FDA designations for its potential in treating relapsed/refractory conditions. The event facilitated valuable industry discussions on innovative therapeutic solutions.

Read more →
-SNTI
Feb 11, 2026
SNTIPhases

Senti Biosciences Completes Enrollment in Phase 1 Clinical Trial of SENTI-202 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Senti Biosciences has completed enrollment in its Phase 1 clinical trial for SENTI-202, a CAR NK cell therapy targeting relapsed or refractory acute myeloid leukemia (R/R AML). The trial showed promising results, including durable complete remissions and a favorable safety profile. The company plans to discuss the next steps with the FDA in 2026, aiming for a pivotal study and potential expansion into newly diagnosed and pediatric AML.

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-SNTI
Feb 4, 2026
SNTIConferences/Events

Senti Biosciences Selected for On-Stage Presentation at Healthcare Conference Taipei 2026

Senti Biosciences has been selected to present at the Healthcare Conference Taipei 2026, where CEO Timothy Lu will discuss the company's Gene Circuit technology. The presentation aims to highlight the company's progress and potential partnerships in cell and gene therapies. The event is expected to attract global investors and strategic partners.

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-SNTI
Jan 15, 2026
SNTIFDA Updates

Senti Biosciences Participates in Virtual Investor CEO Connect Segment to Discuss the Company’s Groundbreaking AML Data at the American Society of Hematology Annual Meeting and Recently Granted RMAT Designation

Senti Biosciences participated in a Virtual Investor CEO Connect Segment, where CEO Timothy Lu discussed the FDA's granting of RMAT designation to SENTI-202, a CAR-NK cell therapy. This investigational therapy is aimed at treating relapsed/refractory AML and builds on previous Orphan Drug Designation. Recent clinical trial data from 20 patients was also shared at the ASH Annual Meeting.

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-SNTI
Jan 9, 2026
SNTIConferences/Events

Senti Bio to Participate in Panel Presentation at Biotech Showcase Alongside the J.P. Morgan Annual Healthcare Conference

Senti Biosciences, Inc. will participate in the Biotech Showcase 2026, with CEO Dr. Timothy Lu as a panelist. The panel will focus on advancements in cell and gene therapies. The event, scheduled for January 12-14, 2026, in San Francisco, serves as a key networking platform for biotech companies and investors.

Read more →
-SNTI
Dec 9, 2025
SNTIFDA Updates

Senti Bio Receives FDA Regenerative Medicine Advanced Therapy (RMAT) Designation for SENTI-202 in the Treatment of Adults with Relapsed or Refractory Acute Myeloid Leukemia

Senti Biosciences has received FDA Regenerative Medicine Advanced Therapy designation for its investigational cell therapy, SENTI-202, aimed at treating relapsed or refractory acute myeloid leukemia (AML). This designation underscores the urgent need for improved therapies in this area and highlights SENTI-202's potential to transform treatment outcomes. The therapy has shown promising clinical results, as presented at the recent ASH Annual Meeting.

Read more →
-SNTI
Dec 9, 2025
SNTIPhases

Senti Bio Announces Updated SENTI-202 Clinical Data from Ongoing Phase 1 Trial in Relapsed or Refractory Acute Myeloid Leukemia Patients, Demonstrating Deep, MRD Negative, Durable Complete Remissions and a Favorable Safety Profile

Senti Bio has announced promising results from its ongoing Phase 1 trial of SENTI-202, a CAR NK cell therapy for relapsed or refractory Acute Myeloid Leukemia (R/R AML). The data presented at the ASH Annual Meeting highlights deep, durable complete remissions and a favorable safety profile. The therapy has received RMAT designation from the FDA, validating its potential to address unmet medical needs in AML treatment.

Read more →
-SNTI
Dec 4, 2025
SNTIConferences/Events

Senti Bio to Host Conference Call and Webcast to Discuss SENTI-202 Clinical Data Being Presented at the American Society of Hematology (ASH) Annual Meeting 2025 on Tuesday, December 9th at 8:00 AM ET

Senti Bio will host a conference call on December 9, 2025, to discuss updated clinical results for SENTI-202, a CAR-NK cell therapy targeting hematologic malignancies. The call will feature key executives and a hematologist involved in the study. SENTI-202 aims to selectively eliminate cancer cells while protecting healthy bone marrow.

Read more →
-SNTI
Nov 13, 2025
SNTIPhases

Senti Bio Reports Third Quarter 2025 Financial Results and Confirms Next Clinical Data Readout for Phase 1 SENTI-202 Study in Acute Myeloid Leukemia (AML) at the American Society of Hematology Annual Meeting in December

Senti Biosciences reported its third quarter 2025 financial results and announced plans to present clinical data from its Phase 1 SENTI-202 study at the upcoming ASH Annual Meeting. The data will focus on patients with relapsed/refractory acute myeloid leukemia (AML) and aims to demonstrate the efficacy and safety of their Gene Circuit technology. The company is actively expanding patient enrollment and achieving significant milestones in its clinical development.

Read more →
-SNTI
Nov 3, 2025
SNTIConferences/Events

Senti Bio to Present Updated Clinical Results of First-in-Class Logic Gated CD33/FLT3 Cell Therapy, SENTI-202, at the American Society of Hematology (ASH) Annual Meeting 2025

Senti Bio announced it will present updated clinical results for its SENTI-202 therapy at the ASH Annual Meeting in December 2025. This first-in-class cell therapy targets CD33 and FLT3 in relapsed/refractory acute myeloid leukemia (AML) while protecting healthy cells. The company aims to address the significant unmet need for effective AML treatments.

Read more →
-SNTI
Oct 16, 2025
SNTIConferences/Events

Senti Bio to Present at Chardan's 9th Annual Genetic Medicines Conference

Senti Biosciences, Inc. announced that CEO Timothy Lu will present at Chardan's 9th Annual Genetic Medicines Conference on October 21, 2025, in New York. The company is focused on developing next-generation cell and gene therapies using its Gene Circuit platform. Management will also hold one-on-one meetings with investors during the event.

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-SNTI
Oct 6, 2025
SNTIConferences/Events

Senti Bio to Present at BioJapan

Senti Biosciences, Inc. will present at BioJapan from October 8-10, 2025, in Yokohama, Japan. CEO Timothy Lu will deliver a presentation on October 9, focusing on the company's Gene Circuit platform for cell and gene therapies. Senti Bio will also engage with investors through one-on-one meetings and has a booth at the event.

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-SNTI
Sep 18, 2025
SNTIConferences/Events

Senti Bio to Present at the MedInvest Biotech & Pharma Conference

Senti Biosciences, Inc. announced that Dr. Kanya Rajangam will present at the MedInvest Biotech & Pharma Conference on September 24, 2025. The presentation will focus on their proprietary Gene Circuit platform, which is aimed at developing advanced cell and gene therapies. Additionally, management will hold one-on-one meetings with investors during the conference.

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-SNTI
Sep 2, 2025
SNTIConferences/Events

Senti Bio to Present at the H.C. Wainwright 27th Annual Global Investment Conference

Senti Biosciences, Inc. will present at the H.C. Wainwright 27th Annual Global Investment Conference on September 8, 2025. CEO Timothy Lu will discuss the company's advancements in cell and gene therapies using their Gene Circuit platform. The event will also include opportunities for in-person meetings with investors. A live video webcast of the presentation will be available.

Read more →
-SNTI
Aug 14, 2025
SNTIConferences/Events

Senti Biosciences to Present at the Webull Financial Corporate Connect Webinar Series: Biotech/MedTech

Senti Biosciences, a clinical-stage biotech firm, will present at the Webull Financial Corporate Connect Webinar Series from August 19-21, 2025. CEO Timothy Lu will lead the presentation on their innovative Gene Circuit platform, which aims to develop advanced cell and gene therapies. This event highlights Senti Bio's commitment to addressing incurable diseases.

Read more →
-SNTI
Aug 12, 2025
SNTIPhases

Senti Bio Participates in Virtual Investor “What This Means” Segment Discussing The Phase 2 Dose and Schedule Selection for SENTI-202 in its Clinical Trial for Acute Myeloid Leukemia

Senti Bio participated in a virtual investor segment discussing its Phase 2 dose selection for SENTI-202, a CAR-NK cell therapy targeting acute myeloid leukemia. Dr. Kanya Rajangam highlighted the therapy's potential as a first-in-class treatment for relapsed/refractory hematologic malignancies. The segment reflects Senti Bio's commitment to developing advanced therapies using its Gene Circuit platform.

Read more →
-SNTI
Aug 7, 2025
SNTIPhases

Senti Bio Reports Second Quarter 2025 Financial Results and Confirms Next Data Milestone for Phase 1 SENTI-202 Study in Acute Myeloid Leukemia (AML) Expected Q4 2025

Senti Biosciences reported its Q2 2025 financial results and highlighted advancements in its Phase 1 SENTI-202 study for Acute Myeloid Leukemia (AML). The company has completed dose finding and confirmed the recommended Phase 2 dose, now entering the dose expansion phase. Additionally, Senti Bio received Orphan Drug Designation for SENTI-202 and anticipates releasing more data by the end of the year.

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-SNTI
Aug 5, 2025
SNTIPhases

Senti Bio Determines Recommended Phase 2 Dose (RP2D) in Phase 1 Study of SENTI-202 for the Treatment of Relapsed/Refractory Hematologic Malignancies, Including Acute Myeloid Leukemia

Senti Biosciences has established the recommended Phase 2 dose (RP2D) for its investigational therapy SENTI-202 in a Phase 1 study targeting relapsed/refractory hematologic malignancies, including acute myeloid leukemia (AML). The RP2D is set at 1.5 x 10^9 CAR+ NK cells administered in a specific schedule. Preliminary results indicate a favorable safety profile and significant remission rates among patients. The company plans to release further clinical data by year-end.

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-SNTI
Jul 22, 2025
SNTIConferences/Events

Senti Biosciences Participates in the Virtual Investor “What’s Your Story” Summer Spotlight On-Demand Conference

Senti Biosciences participated in the Virtual Investor 'What’s Your Story' Summer Spotlight On-Demand Conference, where CEO Timothy Lu discussed his commitment to the company and its innovative programs. The on-demand video is available for viewing on the company's website and virtual investor platform. Senti Bio focuses on developing next-generation cell and gene therapies using its proprietary Gene Circuit platform.

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Competitive Position
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