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SEP-631

Phase 1

Healthy Volunteers | Small molecule | Other |Septerna, Inc.|Last Updated: Apr 21, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment120

FDA Designations

No designations recorded

Clinical trial landscape

SEP-631 · 1 trial · 1 indication

Phase 1 1
NCT07069036A Study to Evaluate Single and Multiple Doses of SEP-631 in Healthy Adult VolunteersHealthy Volunteers
COMPLETED120 Analytics
PHASE1COMPLETED
A Study to Evaluate Single and Multiple Doses of SEP-631 in Healthy Adult Volunteers
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Study Endpoints

Primary Endpoints

Frequency of treatment emergent adverse events
From enrollment to end of follow up visit, up to approximately 2 months

Secondary Endpoints

Plasma PK of SEP-631 after single and multiple doses
From enrollment to end of treatment period, up to approximately 14 days
Plasma PK of SEP-631 under fed and fasted conditions
From enrollment to end of treatment period, up to approximately 14 days
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Single Ascending DoseEXPERIMENTAL -
Multiple Ascending DoseEXPERIMENTAL -
Food EffectEXPERIMENTAL -

Interventions

NameTypeDescription
SEP-631DRUGOral, tablet
PlaceboOTHEROral, tablet
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Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Subjects who are able and willing to provide informed consent 2. Aged 18 to 60 years at the time of consent 3. Have a BMI within the range 18.5 to 32.0 kg/m2 4. In general good health Exclusion Criteria: 1. Any condition, which in the investigator's opinion might jeopardize...

Countries:Australia
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Recent Changes (Last 90 Days)

MEDIUMMay 26, 2026NCT07069036TRIAL_REMOVED: changed
LOWMay 24, 2026NCT07069036studyFirstPostDate: changed

Frequently asked questions about SEP-631

What is SEP-631?

SEP-631 is an investigational small molecule being developed by Septerna, Inc. (NASDAQ: SEPN). It is currently in Phase 1 clinical development for use in healthy volunteers. The drug is not approved and remains under investigation.

What is SEP-631 used for?

SEP-631 is being studied for use in healthy volunteers. It is an investigational small molecule in Phase 1 clinical development. The ongoing research aims to evaluate its safety and tolerability in this population.

Who makes SEP-631?

SEP-631 is being developed by Septerna, Inc., a biopharmaceutical company traded on NASDAQ under the ticker SEPN. The company is conducting clinical trials to evaluate the drug in healthy volunteers.

What phase is SEP-631 in?

SEP-631 is in Phase 1 clinical development. It is an investigational drug being studied in healthy volunteers. The drug is not FDA approved and remains in clinical trials.

What clinical trials is SEP-631 in?

SEP-631 has one completed Phase 1 trial, NCT07069036, which evaluated single and multiple doses in healthy adult volunteers. The study enrolled 120 participants in Australia and was randomized, double-blind, and controlled.