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SP-103

Phase 2

Moderate to Severe Acute Lower Back Pain | Small molecule | Musculoskeletal |Scilex Holding Company|Last Updated: May 24, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment75
FDA Designations
FAST_TRACK
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT05096494Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back PainPHASE2 COMPLETED 75Apr 29, 2022May 30, 2023May 24, 202410 United States
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Study Endpoints
Primary Endpoints
Adverse Events
28 days
Numeric Pain Rating Scale (0-10, 0 is no pain, 10 is worst pain imaginable)
7 days
Secondary Endpoints
Oswestry Disability Index (0-100, 0 is with no disability, 100 is the maximum disability)
Day 7 and 28
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
SP-103EXPERIMENTALOne SP-103 transdermal system is worn 12 hours per day for 28 days on the lower back.
PlaceboPLACEBO_COMPARATOROne placebo transdermal system is worn for 12 hours per day for 28 days on the lower back
Interventions
NameTypeDescription
SP-103DRUGSP-103 topical system is worn daily for 12 hours per day for 28 days
PlaceboDRUGPlacebo topical system is worn daily for 12 hours per day, for 28 days
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: * Able and willing to read, write, and understand the informed consent prior to beginning any study procedures. * Male or female, age 18 to 75 years (inclusive). * Based on medical history, current episode of lower back pain (LBP) must have been present for not more than 3 month...

Countries:United States
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