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EXS21546 for

Phase 1

Oncology | Small molecule | Oncology |Recursion Pharmaceuticals, Inc.|Last Updated: May 16, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT047271383-part Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EXS21546PHASE1 COMPLETED 64Dec 8, 2020May 12, 2022May 16, 20221 United Kingdom
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Study Endpoints
Primary Endpoints
Number of participants with treatment emergent Adverse Events
1 month
EXS21546 and Metabolite Area under the plasma concentration versus time curve (AUC)
17 days
EXS21546 and Metabolite Peak Plasma Concentration (Cmax)
17 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
EXS21546 Powder for Oral SuspensionEXPERIMENTALEXS21546 Powder for Oral Suspension
PlaceboPLACEBO_COMPARATORPlacebo Powder for Oral Suspension
EXS21546 Granule in CapsuleEXPERIMENTALEXS21546 Granule in Capsule
Interventions
NameTypeDescription
EXS21546 Powder for Oral SuspensionDRUGEXS21546 Powder for Oral Suspension
EXS21546 Granule in CapsuleDRUGEXS21546 Granule in Capsule
MidazolamOTHERInteraction
Food EffectOTHERFed/Fasted
Placebo Powder for Oral SuspensionOTHERPlacebo Powder for Oral Suspension
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Eligibility Criteria
Age Range18 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * BMI 18.0 to 30.0 kg/m2 * Weight ≥60 kg * Must adhere to contraception requirements Exclusion Criteria: * Subjects who have received any IMP in a clinical research study within the 90 days prior to Day 1 * Subjects who have previously been administered IMP in this study. * Ev...

Countries:United Kingdom
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