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ZN-A-1041 Formulation 1

Phase 1

Healthy Volunteers | Small molecule | Other |Roche Holding AG|Last Updated: May 11, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

No designations recorded

Clinical trial landscape

ZN-A-1041 Formulation 1 · 1 trial · 1 indication

Phase 1 1
NCT07329972A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy ParticipantsHealthy Volunteers
COMPLETED24 Analytics
PHASE1COMPLETED
A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants
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Study Endpoints

Primary Endpoints

Maximum Observed Concentration (Cmax)
Days 1 to 8, 11 to 14, and 17 to 20
Area Under the Concentration-time Curve (AUC) From Hour 0 to the Last Measurable Concentration (AUC0-t)
Days 1 to 8, 11 to 14, and 17 to 20
AUC Extrapolated to Infinity (AUC0-∞)
Days 1 to 8, 11 to 14, and 17 to 20
Geometric Mean Ratio and Associated 90% Confidence Interval (CI) of Cmax, AUC0-t, and AUC0-∞
Days 1 to 8, 11 to 14, and 17 to 20

Secondary Endpoints

ZN-A-1041 PK Parameters Time to Maximum Observed Concentration (Tmax) for All Treatments
Days 1 to 8, 11 to 14, and 17 to 20
ZN-A-1041 Apparent Terminal Elimination Rate Constant (λz) for All Treatments
Days 1 to 8, 11 to 14, and 17 to 20
ZN-A-1041 Apparent Terminal Elimination Half-life (t1/2) for All Treatments
Days 1 to 8, 11 to 14, and 17 to 20
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Sequence 1EXPERIMENTAL -
Sequence 2EXPERIMENTAL -
Sequence 3EXPERIMENTAL -
Sequence 4EXPERIMENTAL -
Sequence 5EXPERIMENTAL -
Sequence 6EXPERIMENTAL -
Sequence 7EXPERIMENTAL -
Sequence 8EXPERIMENTAL -

Interventions

NameTypeDescription
ZN-A-1041 Formulation 1DRUGParticipants will receive a single dose of ZN-A-1041 Formulation 1 on each specified treatment.
ZN-A-1041 Formulation 2DRUGParticipants will receive a single dose of ZN-A-1041 Formulation 2 on each specified treatment.
RabeprazoleDRUGParticipants will receive an oral administration of rabeprazole twice daily (BID) on days 9, 10, 15, and 16 and a single dose on Days 11 and 17.
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Body mass index (BMI) within the range of 18 to 32 kg/m2, inclusive * In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, and vital signs, as determined by the investigator, at Screening and Check-in, as app...

Countries:United States
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Frequently asked questions about ZN-A-1041 Formulation 1

What is ZN-A-1041 Formulation 1 used for?

ZN-A-1041 Formulation 1 is an investigational small molecule being studied in healthy volunteers. It is not approved for any disease and is currently in Phase 1 clinical development. The completed trial evaluated its pharmacokinetics, specifically how food and a proton pump inhibitor affect its absorption and processing in the body.

Who makes ZN-A-1041 Formulation 1?

ZN-A-1041 Formulation 1 is being developed by Roche Holding AG, traded on the OTC market under the ticker RHHBY. The company is conducting clinical research on this investigational small molecule in healthy volunteers.

What phase is ZN-A-1041 Formulation 1 in?

ZN-A-1041 Formulation 1 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities. The single Phase 1 trial has been completed, and the drug is not currently in any active clinical trials.

What clinical trials is ZN-A-1041 Formulation 1 in?

ZN-A-1041 Formulation 1 has one completed clinical trial, NCT07329972, titled 'A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants.' This Phase 1 study enrolled 24 healthy adults in the United States and was a controlled, randomized trial.

Is ZN-A-1041 Formulation 1 the same as ZN-A-1041?

ZN-A-1041 Formulation 1 is a specific formulation of the investigational drug ZN-A-1041. The clinical trial NCT07329972 evaluates this particular formulation in healthy volunteers. No other alternative names for this drug have been disclosed.