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RO7830698

Phase 1

Chronic Obstructive Pulmonary Disease (COPD) | Small molecule | Respiratory |Roche Holding AG|Trials Updated: Oct 20, 2026

RO7830698 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Sep 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment104

FDA Designations

No designations recorded

RO7830698 clinical trials

RO7830698 · 1 trial · 2 indications

Phase 1 1
NCT07822334A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary DiseaseChronic Obstructive Pulmonary Disease (COPD)
RECRUITING104 Analytics
PHASE1RECRUITING
A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD)Unlock trial analytics

Study Endpoints

Primary Endpoints

Part 1: Incidence and Severity of Adverse Events (AEs)
Up to approximately 50 weeks
Part 2: Incidence and Severity of AEs
Up to approximately 44 weeks
Part 1: Incidence of Dose-limiting Adverse Events (DLAEs)
Up to approximately 50 weeks
Part 2: Incidence of DLAEs
Up to approximately 44 weeks

Secondary Endpoints

Part 1 and Part 2: Plasma Concentration of RO7830698
Part 1: Up to approximately 50; Part 2: Up to approximately 44 weeks
Part 1: Bioavailability (F) of RO7830698
Up to approximately 50 weeks
Part 1: Area Under the Concentration-Time Curve From Time 0 To Infinity (AUC inf) of RO7830698
Up to approximately 50 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part 1: Single Ascending Dose (SAD)EXPERIMENTALHealthy participants will receive single doses of RO7830698 or placebo.
Part 2: Multiple Ascending Dose (MAD)EXPERIMENTALParticipants with COPD will receive multiple doses of RO7830698 or placebo.

Interventions

NameTypeDescription
RO7830698DRUGParticipants will receive RO7830698 as per the schedule described in the protocol.
PlaceboDRUGParticipants will receive placebo as per the schedule described in the protocol.
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Eligibility Criteria

Age Range18 Years to 80 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: All participants: * Body mass index (BMI) between 18 and 32 kilograms per meter square (kg/m2) * Agreement to adhere to the contraception requirements Part 1: * Absence of evidence of any active or chronic disease Part 2: * Confirmed diagnosis of COPD for \> 6 months, as de...

Countries:United Kingdom
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Recent Changes (Last 90 Days)

LOWOct 20, 2026NCT07822334Status: NOT_YET_RECRUITING → RECRUITING
LOWOct 20, 2026NCT07822334Status: NOT_YET_RECRUITING → RECRUITING
LOWSep 16, 2026NCT07822334NEW_TRIAL: changed
LOWSep 16, 2026NCT07822334NEW_TRIAL: changed
LOWSep 16, 2026NCT07822334NEW_TRIAL: changed

Frequently asked questions about RO7830698

What is RO7830698?

RO7830698 is an investigational small molecule being developed by Roche Holding AG for chronic obstructive pulmonary disease (COPD). It is in Phase 1 clinical development and is being studied in a single recruiting trial that enrolls both healthy participants and participants with COPD.

What is RO7830698 used for in COPD?

RO7830698 is being developed as a treatment for chronic obstructive pulmonary disease (COPD), a respiratory condition. It is investigational and has not been established as a therapy; the current Phase 1 study evaluates it in participants with COPD alongside healthy participants in the United Kingdom.

Who is developing RO7830698?

RO7830698 is being developed by Roche Holding AG, which trades under the ticker RHHBY. Roche is the sponsor of the Phase 1 study of the compound in healthy participants and participants with COPD.

What phase is RO7830698 in?

RO7830698 is in Phase 1 clinical development. It is investigational and is not approved for any use. One Phase 1 trial is currently recruiting, and no trials of RO7830698 have been completed.

What clinical trial is RO7830698 in?

RO7830698 is being studied in trial NCT07822334, titled A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease. The Phase 1 trial is recruiting, is randomized, double-blind, and controlled, plans to enroll 104 participants, and is conducted in the United Kingdom.