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RO7567132 and Atezolizumab

Phase 1

Cancer-Neoplasms | Small molecule | Oncology |Roche Holding AG|Last Updated: Jul 13, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment34

FDA Designations

No designations recorded

Clinical trial landscape

RO7567132 and Atezolizumab · 1 trial · 1 indication

Phase 1 1
NCT06537310A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid TumorsCancer-Neoplasms
ACTIVE NOT_RECRUITING34 Analytics
PHASE1ACTIVE NOT_RECRUITING
A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid Tumors
Cancer-NeoplasmsUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of Participants with Adverse Events (AEs) Graded According to Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE v5.0)
Up to a maximum of 27 months
Percentage of Participants With Dose-limiting Toxicities (DLTs)
From baseline to 3 weeks on study

Secondary Endpoints

Maximum Concentration (Cmax) Derived for RO7567132
Up to a maximum of 24 months
Time of Maximum Concentration (Tmax)
Up to a maximum of 24 months
Minimum Concentration (Cmin)
Up to maximum of 24 Months
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part I: RO7567132 Dose Escalation With or Without AtezolizumabEXPERIMENTAL -
Part II: RO7567132 Backfill With AtezolizumabEXPERIMENTAL -

Interventions

NameTypeDescription
RO7567132 and AtezolizumabDRUGRO7567132 will be administered either as monotherapy or in combination with atezolizumab at a dose and schedule as specified for the respective cohort.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites10

Inclusion Criteria: * Male or female participants aged ≥18 years * Body weight \> 40 kilograms (kg) * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 and Life expectancy of at least 12 weeks * Participants with advanced and/or metastatic solid tumors * Availability and willin...

Countries:AustraliaBelgiumCanadaDenmarkSpain
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Recent Changes (Last 90 Days)

LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed
LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed
LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed

Frequently asked questions about RO7567132 and Atezolizumab

What is RO7567132 and Atezolizumab used for?

RO7567132 and Atezolizumab is an investigational combination being studied for the treatment of advanced solid tumors in patients with cancer. It is currently in Phase 1 clinical development, evaluated as a single agent and in combination with Atezolizumab in participants with advanced solid tumors.

Who makes RO7567132 and Atezolizumab?

RO7567132 and Atezolizumab is being developed by Roche Holding AG, a biopharmaceutical company. Roche is conducting a Phase 1 dose-escalation study of RO7567132 as a single agent and in combination with Atezolizumab in participants with advanced solid tumors.

What phase is RO7567132 and Atezolizumab in?

RO7567132 and Atezolizumab is in Phase 1 clinical development. The drug is investigational and has not been approved by regulatory authorities. It is being studied in a dose-escalation trial for advanced solid tumors, with the trial currently active but not recruiting participants.

What clinical trials is RO7567132 and Atezolizumab in?

RO7567132 and Atezolizumab is being studied in clinical trial NCT06537310, a Phase 1 dose-escalation study as a single agent and in combination with Atezolizumab in participants with advanced solid tumors. The trial has an enrollment of 34 participants and is active but not recruiting.

Is RO7567132 and Atezolizumab the same as Atezolizumab alone?

RO7567132 and Atezolizumab is a combination regimen that includes Atezolizumab, but it is not the same as Atezolizumab alone. The study evaluates RO7567132 as a single agent and in combination with Atezolizumab, meaning the combination is a distinct investigational treatment being tested.