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RO7567132

Phase 1

Cancer-Neoplasms | Small molecule | Oncology |Roche Holding AG|Trials Updated: Oct 1, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment34

FDA Designations

No designations recorded

RO7567132 clinical trials

RO7567132 · 1 trial · 1 indication

Phase 1 1
NCT06537310A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid TumorsCancer-Neoplasms
ACTIVE NOT_RECRUITING34 Analytics
PHASE1ACTIVE NOT_RECRUITING
A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid Tumors
Cancer-NeoplasmsUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of Participants with Adverse Events (AEs) Graded According to Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE v5.0)
Up to a maximum of 27 months
Percentage of Participants With Dose-limiting Toxicities (DLTs)
From baseline to 3 weeks on study

Secondary Endpoints

Maximum Concentration (Cmax) Derived for RO7567132
Up to a maximum of 24 months
Time of Maximum Concentration (Tmax)
Up to a maximum of 24 months
Minimum Concentration (Cmin)
Up to maximum of 24 Months
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part I: RO7567132 Dose Escalation With or Without AtezolizumabEXPERIMENTAL -
Part II: RO7567132 Backfill With AtezolizumabEXPERIMENTAL -

Interventions

NameTypeDescription
RO7567132 and AtezolizumabDRUGRO7567132 will be administered either as monotherapy or in combination with atezolizumab at a dose and schedule as specified for the respective cohort.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites11

Inclusion Criteria: * Male or female participants aged ≥18 years * Body weight \> 40 kilograms (kg) * Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 and Life expectancy of at least 12 weeks * Participants with advanced and/or metastatic solid tumors * Availability and willin...

Countries:AustraliaBelgiumCanadaDenmarkSpain
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Recent Changes (Last 90 Days)

LOWOct 1, 2026NCT06537310lastUpdatePostDate: changed
LOWOct 1, 2026NCT06537310lastUpdatePostDate: changed
LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed
LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed
LOWAug 1, 2026NCT06537310lastUpdatePostDate: changed

Frequently asked questions about RO7567132

What is RO7567132?

RO7567132 is an investigational small molecule developed by Roche Holding AG for the treatment of advanced solid tumors. It is being studied both as a single agent and in combination with atezolizumab in adult patients with cancer. It is currently in Phase 1 clinical development and has not been approved for any indication.

What is RO7567132 used for?

RO7567132 is being evaluated for the treatment of cancer, specifically advanced solid tumors. The Phase 1 study enrolls adults aged 18 years and older with Cancer-Neoplasms. Because it remains investigational, RO7567132 is not approved for any use outside of clinical research.

Who is developing RO7567132?

RO7567132 is being developed by Roche Holding AG, which trades on the OTC market under the ticker RHHBY. Roche is running the clinical program for the asset, including a Phase 1 dose-escalation study in advanced solid tumors that tests the drug alone and in combination with atezolizumab.

What phase is RO7567132 in?

RO7567132 is in Phase 1 clinical development. The only registered trial is a Phase 1 dose-escalation study, and no Phase 2 or Phase 3 trials have been recorded. As an investigational agent, RO7567132 has not received FDA approval and is not available outside of clinical trials.

What clinical trials is RO7567132 in?

RO7567132 is being studied in one active trial, NCT06537310, titled a dose-escalation study of RO7567132 as a single agent and in combination with atezolizumab in participants with advanced solid tumors. The study is active but not recruiting, has enrolled 34 participants, and takes place in Australia, Belgium, Canada, Denmark, and Spain.

Is RO7567132 the same as atezolizumab?

No. RO7567132 and atezolizumab are separate agents. RO7567132 is an investigational small molecule in Phase 1 testing, while atezolizumab is an existing therapy used as the combination partner in the NCT06537310 study. The trial evaluates RO7567132 given alone and together with atezolizumab in advanced solid tumors.