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DMUC5754A

Phase 1

Ovarian Cancer, Pancreatic Cancer | Small molecule | Oncology |Roche Holding AG|Last Updated: Nov 2, 2016

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment77

FDA Designations

No designations recorded

Clinical trial landscape

DMUC5754A · 1 trial · 1 indication

Phase 1 1
NCT01335958Safety and Pharmacokinetics of DMUC5754A Administered Intravenously to Patients With Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic CancerOvarian Cancer, Pancreatic Cancer
COMPLETED77 Analytics
PHASE1COMPLETED
Safety and Pharmacokinetics of DMUC5754A Administered Intravenously to Patients With Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer
Ovarian Cancer, Pancreatic CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of dose-limiting toxicities (DLTs)
Up to 21 days
Nature of dose-limiting toxicities (DLTs) graded per NCI CTCAE v4.0
Up to 21 days

Secondary Endpoints

Incidence of adverse events
Up to 1 year
Nature of adverse events graded per NCI CTCAE v4.0
Up to 1 year
Severity of adverse events
Up to 1 year
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
AEXPERIMENTAL -

Interventions

NameTypeDescription
DMUC5754ADRUGEscalating intravenous dose
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites4

Inclusion Criteria: * Life expectancy of at least 12 weeks * Documented willingness to use an effective means of contraception for women of childbearing potential * Measurable disease with at least one lesion that can be accurately measured in at least one dimension Inclusion Criteria Specific to ...

Countries:United States
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Frequently asked questions about DMUC5754A

What is DMUC5754A used for?

DMUC5754A is an investigational small molecule being studied for the treatment of ovarian cancer and pancreatic cancer. It is in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes DMUC5754A?

DMUC5754A is being developed by Roche Holding AG, which trades under the ticker RHHBY. The drug is currently in Phase 1 clinical development for ovarian cancer and pancreatic cancer.

What phase is DMUC5754A in?

DMUC5754A is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or other regulatory agencies. One Phase 1 trial has been completed.

What clinical trials is DMUC5754A in?

DMUC5754A has one completed clinical trial, NCT01335958, which evaluated its safety and pharmacokinetics in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer. The trial enrolled 77 participants in the United States.

Is DMUC5754A FDA approved?

DMUC5754A is not FDA approved. It is an investigational drug currently in Phase 1 clinical development for ovarian cancer and pancreatic cancer. Its safety and efficacy have not been established.