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REGN668: Rate 1

Phase 1

Healthy | Small molecule | Other |Regeneron Pharmaceuticals, Inc.|Last Updated: Mar 14, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment36
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01484600Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN668 Administered Subcutaneously to Healthy VolunteersPHASE1 COMPLETED 36Dec 1, 2011Feb 1, 2012Mar 14, 20121 United States
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Study Endpoints
Primary Endpoints
Incidence and severity of treatment-emergent adverse events (TEAEs)
Baseline through day 64 (end of study)
Secondary Endpoints
Pharmacokinetic (PK) profile of REGN668
Baseline through day 64
Incidence of anti-REGN668 antibodies
Day 29 and Day 64
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Group 1EXPERIMENTAL -
Group 2EXPERIMENTAL -
Interventions
NameTypeDescription
REGN668: Injection Rate 1DRUGSubjects will receive REGN668 via SC injection
REGN668: Injection Rate 2DRUGSubjects will receive study drug via alternate delivery (if necessary)
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Male or female subjects 18 to 55 years of age. 2. Body weight between 60 kg and 80 kg, body mass index between 20 and 30 kg/m2 inclusive. 3. NHV as evidenced by comprehensive clinical assessment (detailed medical history and complete physical examination). 4. Normal resting b...

Countries:United States
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