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REGN421

Phase 1

Advanced Solid Malignancies | Small molecule | Oncology |Regeneron Pharmaceuticals, Inc.|Last Updated: Mar 26, 2014

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment83

FDA Designations

No designations recorded

Clinical trial landscape

REGN421 · 1 trial · 1 indication

Phase 1 1
NCT00871559A Multiple-Ascending-Dose Study of the Safety and Tolerability of REGN421(SAR153192) in Patients With Advanced Solid MalignanciesAdvanced Solid Malignancies
COMPLETED83 Analytics
PHASE1COMPLETED
A Multiple-Ascending-Dose Study of the Safety and Tolerability of REGN421(SAR153192) in Patients With Advanced Solid Malignancies
Advanced Solid MalignanciesUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety and tolerability
18 months

Secondary Endpoints

Preliminary evidence of antitumor activity
18 months
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Q2WEXPERIMENTALREGN421 (SAR153192) taken once every two weeks (Q2W)

Interventions

NameTypeDescription
REGN421(SAR153192)DRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites8

Inclusion Criteria: 1. Male or female 18 years of age or older 2. Histologically diagnosis of advanced solid malignancy, with no standard therapeutic options of proven benefit. 3. Patients with measurable or non-measurable disease 4. At least 6 weeks must have elapsed since the last dose of bevaciz...

Countries:United States
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Frequently asked questions about REGN421

What is REGN421 used for?

REGN421 is an investigational small molecule being studied for the treatment of advanced solid malignancies. It is in Phase 1 clinical development and has been evaluated in a completed trial involving patients with advanced solid tumors.

Who makes REGN421?

REGN421 is being developed by Regeneron Pharmaceuticals, Inc., a biopharmaceutical company traded on NASDAQ under the ticker symbol REGN. The drug is currently in Phase 1 clinical development for advanced solid malignancies.

What phase is REGN421 in?

REGN421 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 trial of REGN421 in advanced solid malignancies has been completed.

What clinical trials is REGN421 in?

REGN421 has been studied in one clinical trial, NCT00871559, titled 'A Multiple-Ascending-Dose Study of the Safety and Tolerability of REGN421(SAR153192) in Patients With Advanced Solid Malignancies.' This Phase 1 trial was completed and enrolled 83 participants in the United States.

Is REGN421 the same as SAR153192?

Yes, REGN421 is also known as SAR153192. The clinical trial NCT00871559 refers to the drug as REGN421(SAR153192), indicating that both names are used for the same investigational agent being developed for advanced solid malignancies.