Recent Updates
Recently added Catalysts

REGN22530

Phase 1

Primary Open Angle Glaucoma (POAG) | Small molecule | Ophthalmology |Regeneron Pharmaceuticals, Inc.|Last Updated: Jun 30, 2026

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindCONTROLLEDDMC
Total Trials1
Total Enrollment271

FDA Designations

No designations recorded

Clinical trial landscape

REGN22530 · 1 trial · 2 indications

Phase 1 1
NCT07675824REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular HypertensionPrimary Open Angle Glaucoma (POAG)
NOT YET_RECRUITING271 Analytics
PHASE1NOT YET_RECRUITING
REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension
Primary Open Angle Glaucoma (POAG)Unlock trial analytics

Study Endpoints

Primary Endpoints

Occurrence of Treatment Emergent Adverse Events (TEAEs)
Up to week 16

Part A and B

Change from baseline in mean diurnal IOP in the study eye
At day 85

Part C

Secondary Endpoints

Concentrations of REGN22530 in serum
Up to week 24
Occurrence of Anti-Drug Antibodies (ADAs) to REGN22530 in serum
Up to week 24
Magnitude of ADAs to REGN22530 in serum
Up to week 24
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Phase 1 Part AEXPERIMENTAL -
Phase 1 Part BEXPERIMENTAL -
Phase 2 Part CEXPERIMENTAL -

Interventions

NameTypeDescription
REGN22530DRUGAdministered per the protocol
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Key Inclusion Criteria: 1. Diagnosis of OHT or POAG of mild to moderate severity as described in the protocol 2. Best-Corrected Visual Acuity (BCVA) of ≥35 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent of better than or equal to 20/200) in the study eye on day 1 3. ...

Unlock Eligibility Criteria

Recent Changes (Last 90 Days)

LOWJun 30, 2026NCT07675824NEW_TRIAL: changed
LOWJun 30, 2026NCT07675824NEW_TRIAL: changed
LOWJun 30, 2026NCT07675824NEW_TRIAL: changed

Frequently asked questions about REGN22530

What is REGN22530 used for?

REGN22530 is an investigational small molecule being developed for Primary Open Angle Glaucoma (POAG). It is also being studied in Ocular Hypertension (OHT). The drug is currently in Phase 1 clinical development and has not been approved by the FDA.

Who makes REGN22530?

REGN22530 is being developed by Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN). The company is conducting a Phase 1 clinical trial to evaluate the drug in adults with Primary Open Angle Glaucoma or Ocular Hypertension.

What phase is REGN22530 in?

REGN22530 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The ongoing Phase 1 trial is a randomized, double-blind, controlled study that is not yet recruiting participants.

What clinical trials is REGN22530 in?

REGN22530 is being studied in one Phase 1 clinical trial, NCT07675824, titled 'REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension'. The trial has an enrollment of 271 participants and is currently not yet recruiting.

Is REGN22530 the same as any other drug?

REGN22530 is the only name provided for this investigational drug. It is a small molecule being developed by Regeneron Pharmaceuticals for the treatment of Primary Open Angle Glaucoma and Ocular Hypertension.