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REGN1908

Phase 3

Allergic Conjunctivitis | Small molecule | Other |Regeneron Pharmaceuticals, Inc.|Last Updated: May 8, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06602726A Study to Demonstrate How Well REGN1908-1909 Works in Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Cat AllergyPHASE3 COMPLETED 64Nov 6, 2024Aug 2, 2025May 8, 20264 United States, Canada
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Study Endpoints
Primary Endpoints
Ocular itch score
At day 8 post-Conjunctival Allergen Challenge (CAC)

Assessed using the Ora Calibra® Conjunctival Allergen Challenge Ocular Itching Scale, a 0-4 point scale where 0= none and 4= incapacitating itch, 0.5 unit increments

Secondary Endpoints
Conjunctival redness score
At day 8 post-CAC
Percent change in cat titrated Skin prick test (tSPT)
Baseline and day 8
Tearing score
At day 8 post-CAC
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
REGN1908-1909EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
REGN1908DRUGAdministered per the protocol
REGN1909DRUGAdministered per the protocol
PlaceboDRUGAdministered per the protocol
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites4

Key Inclusion Criteria: 1. Documented or participant-reported history of moderate to severe cat allergy for at least 2 years with bothersome ocular symptoms being near cat(s) 2. Positive SPT with cat allergen extract (mean wheal diameter at least 5 mm greater than the negative control) at screening...

Countries:United StatesCanada
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Recent Changes (Last 90 Days)
MEDIUMJun 8, 2026NCT06602726TRIAL_REMOVED: changed
MEDIUMJun 8, 2026NCT06602726TRIAL_REMOVED: changed
MEDIUMJun 8, 2026NCT06602726TRIAL_REMOVED: changed
MEDIUMJun 8, 2026NCT06602726TRIAL_REMOVED: changed
MEDIUMJun 8, 2026NCT06602726TRIAL_REMOVED: changed