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Ondansetron

Phase 1

Healthy | Small molecule | Other |Dr. Reddy's Laboratories Ltd|Last Updated: Jan 19, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment52
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01511705Bioequivalence Study for Ondansetron Hydrochloride Tablets 8 mg Under Fasting ConditionPHASE1 COMPLETED 26Oct 1, 2006Oct 1, 2006Jan 19, 20121 India
NCT01511718Bioequivalence Study for Ondansetron Hydrochloride Tablets 8 mg Under Fed ConditionPHASE1 COMPLETED 26Oct 1, 2006Oct 1, 2006Jan 19, 20121 India
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Study Endpoints
Primary Endpoints
Area unde curve (AUC)
First one was within 1 hour prior to drug administration (0.0) and others at 0.33,0.67,1,1.33, 1.67, 2, 2.5, 3, 3.5,4,6,9,12,15,18 and 24 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Ondansetron Hydrochloride Tablets 8 mgEXPERIMENTALOndansetron Hydrochloride Tablets 8 mg of Dr. Reddy's Laboratories Limited
Zofran Tablets 8 mgACTIVE_COMPARATORZofran Tablets 8 mg of GlaxoSmithKline
Interventions
NameTypeDescription
Ondansetron HydrochlorideDRUGOndansetron Hydrochloride Tablets 8 mg
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Eligibility Criteria
Age Range18 Years — 45 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Subjects who provide written informed consent. * Subjects who were healthy adults within 18 and 45 years of age (both inclusive). * Body mass index of ≥ 18 kg/m2 and ≤ 25 kg/m2, with body weight not less than 50 kg. * Subjects who had normal health as determined by medical his...

Countries:India
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