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Lamictal

Phase 1

Healthy | Small molecule | Other |Dr. Reddy's Laboratories Ltd|Last Updated: Jan 20, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01513720Bioequivalence Study for Lamotrigine Tablets 200 mg Under Fasting ConditionPHASE1 COMPLETED 20Dec 1, 2002Dec 1, 2002Jan 20, 20121 United States
NCT01513681Bioequivalence Study for Lamotrigine Tablets 200 mg Under Fed ConditionPHASE1 COMPLETED 20Nov 1, 2002Nov 1, 2002Jan 20, 20121 United States
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Study Endpoints
Primary Endpoints
Area under curve (AUC)
Pre-dose 0.5,1,1.5,2,2.5,3,3.5,4,5,6,8,12,24,36,48,72,96,120 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Lamotrigine Tablets 200 mgEXPERIMENTALLamotrigine Tablets 200 mg of Dr. Reddy's Laboratories Limited
Lamictal® 200 mg TabletsACTIVE_COMPARATORLamictal® 200 mg Tablets of GlaxoSmithKline Inc
Interventions
NameTypeDescription
LamotrigineDRUGLamotrigine Tablets 200 mg
Lamictal®DRUGLamictal® 200 mg Tablets
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Eligibility Criteria
Age Range20 Years — 44 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Healthy males and females at least 18 years of age inclusive 2. Informed of the nature of the study and given written informed consent 3. Have a body weight within 15% of the appropriate range as defined in the 1983 Metropolitan Life Company tables and weighing at least 100 l...

Countries:United States
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