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Cymbalta

Phase 1

Healthy | Small molecule | Other |Dr. Reddy's Laboratories Ltd|Last Updated: Nov 14, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMCBiomarker
Total Trials2
Total Enrollment152
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02291341Bioavailability Study of Duloxetine Delayed-Relase Capsules 60 mg Under Fed ConditionPHASE1 COMPLETED 76May 1, 2008May 1, 2008Nov 14, 20141 India
NCT02291367Bioavailability Study of Duloxetine Delayed-Release Capsules 60 mg Under Fasting ConditionPHASE1 COMPLETED 76May 1, 2008May 1, 2008Nov 14, 20141 India
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Study Endpoints
Primary Endpoints
Area under curve (AUC)
1.0, 2.0,3.0, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 9.0, 10.0, 11.0, 12.0, 24.0, 36.0, 48.0,60.0 and 72.0 hours post dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Duloxetine Delayed-Release Capsules, 60 mgEXPERIMENTALDuloxetine Delayed-Release Capsules, 60 mg of Dr. Reddys Laboratories Limited
CymbaltaACTIVE_COMPARATORCymbalta® 60 mg capsule of Eli Lilly and Company
Interventions
NameTypeDescription
DuloxetineDRUGDuloxetine Delayed-Release Capsules 60 mg
Cymbalta®DRUG60 mg capsule of Eli Lilly and Company
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Eligibility Criteria
Age Range18 Years — 45 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. The subjects should be healthy human between 18 and 45 years. 2. The subjects should be screened within 21 days prior to the administration of first dose of the study drug. 3. The subjects should have a BMI between 18.5 and 24.9 weight in kg/ height2 in meter. 4. The subjects...

Countries:India
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