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RHB-102

Phase 3

Gastroenteritis | Small molecule | Other |Redhill Biopharma Ltd.|Last Updated: Feb 20, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment330
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02246439BEKINDA (Ondansetron 24 mg Bimodal Release Tablets) for Vomiting Due to Presumed Acute Gastroenteritis or GastritisPHASE3 COMPLETED 330Dec 8, 2014Feb 16, 2017Feb 20, 201926 United States
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Study Endpoints
Primary Endpoints
Treatment Success From 30 Minutes Through 24 Hours After First Dose of Study Medication - ITT Population
24 Hours

Number of patients without further vomiting, without rescue medication, and who were not given intravenous hydration from 30 minutes post first dose until 24 hours post dose

Secondary Endpoints
Responders Through 4 Days After First Dose of Study Medication - ITT Population
4 Days
Number of Participants Who Vomited - ITT Population
24 Hours
Number of Patients Receiving Rescue Antiemetic Therapy - ITT Population
24 Hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
RHB-102EXPERIMENTALRHB-102, Bimodal Release Ondansetron Tablets
PlaceboPLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
RHB-102DRUGRHB-102, Bimodal Release Ondansetron Tablets
Placebo Oral TabletDRUGPlacebo
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Eligibility Criteria
Age Range12 Years — 85 Years
SexALL
Healthy VolunteersNo
Study Sites26

Inclusion Criteria: * Patients must have vomited at least twice in the 4 hours preceding signing informed consent. A vomiting episode is defined as an episode of forceful expulsion of stomach contents. Retching if a patient has already emptied his or her gastric contents is also considered vomiting...

Countries:United States
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