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PureTech Health plc

PRTCYFDA catalysts, PDUFA dates & pipeline intelligence
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Volume
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Cash Data

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Key Stats

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Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

PRTCY Catalyst Timeline

Dated clinical, regulatory and corporate events for PureTech Health plc

Catalyst Timeline

Dated clinical, regulatory & corporate events for PureTech Health plc

10Total events
2Upcoming
1Tier-1 (high impact)
2026 to 2027Coverage

Upcoming catalysts 2

T2Timing Guidance
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LYT-200
TBD
T2Timing Guidance
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LYT-200

Event history 5

▲Full ResultsLYT-200Clinical Data
Detailed Phase 1b results including depth of response and safety across 101 patients
relapsed/refractory high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML)source ↗
▲Oral PresentationLYT-200Presentation
Phase 1b results for LYT-200 presented orally at ESMO 2026
relapsed/refractory high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML)source ↗
◆Oral PresentationLYT-200Presentation
Phase 1b topline results for LYT-200 in R/R HR-MDS and AML presented at ESMO 2026
relapsed/refractory high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML)source ↗
▲End Of Phase 1 MeetingLYT-200FDA Meeting
Successful completion of End-of-Phase 1 meeting with U.S. FDA for LYT-200 in R/R HR-MDS
relapsed/refractory (R/R) high-risk myelodysplastic syndromes (HR-MDS)source ↗
▲Fast Track DesignationLYT-200Designation
FDA Fast Track designation granted for LYT-200 plus HMA in R/R HR-MDS
relapsed/refractory (R/R) high-risk myelodysplastic syndromes (HR-MDS)source ↗
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Every PDUFA date, readout, approval and corporate move, tiered by market impact and updated daily.
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Past FDA Catalysts and PDUFA Decisions

How PRTCY actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Valuation Signal
3
Drugs Scored
rNPV / MCap
Top Drug
Top 65%
Micro Cap
(rank 447 of 687)
Percentile Rank
Showing 4 of 4 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Deupirfenidone Small MoleculesNCT05321420Idiopathic Pulmonary FibrosisPhase 3 ACTIVE NOT_RECRUITING 1,340Dec 31, 2025
LYT-200 Small MoleculesCompletedNCT04666688Metastatic CancerPhase 1/2 COMPLETED 44Dec 12, 2024
LYT-200 Small MoleculesCompletedNCT05829226AML, Adult RecurrentPhase 1 COMPLETED 101Dec 31, 2025
LYT-300 Small MoleculesCompletedNCT05129865UndisclosedPhase 1/2 COMPLETED 186Oct 23, 2023
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Clinical Trial Results

Readouts, endpoints and source filings for every PRTCY program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
No hedge fund reported a 13F position in PRTCY for Q2 2026.
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Every 13F position with quarter over quarter share flow and average entry price.
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Shares held by hedge funds each quarter, and who bought or sold.

Ownership Trends

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Insider and institutional ownership, quarter by quarter.

PRTCY Short Interest

Shares sold short, counted twice a month.

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Short % of Float
of tradable shares sold short
5.4K
Shares Sold Short
-5.0% vs prior count
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Days to Cover
trading days of normal volume to buy every short share back
546
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
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Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
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Per-expiry call and put volume, open interest, put-call ratios and implied volatility.
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Real-Time Option Chain

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LastVolOILastVolOI
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Calls vs Puts by Expiry

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Competitive positioning

How PRTCY ranks across every disease it competes in

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See how PRTCY ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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PRTCY News

-PRTCY
Oct 26, 2026
PRTCYPhases

PureTech Presents Phase 1b Results for LYT-200 in Relapsed/Refractory (R/R) High-Risk Myelodysplastic Syndromes (HR-MDS) and Acute Myeloid Leukemia (AML) at ESMO 2026

PureTech Health presented Phase 1b results for LYT-200 at ESMO 2026, showing promising responses in patients with relapsed/refractory high-risk myelodysplastic syndromes and acute myeloid leukemia. The trial demonstrated a favorable safety profile with no serious adverse events. Following a successful FDA meeting, LYT-200 will advance to Phase 2 trials.

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-PRTCY
Oct 19, 2026
PRTCYPhases

PureTech Announces Presentation of Phase 1b Results for LYT-200 in Relapsed/Refractory (R/R) High-Risk Myelodysplastic Syndromes (HR-MDS) and Acute Myeloid Leukemia (AML) at ESMO 2026

PureTech Health announced positive Phase 1b results for LYT-200 in treating relapsed/refractory high-risk myelodysplastic syndromes and acute myeloid leukemia. The results indicate encouraging clinical activity and a favorable safety profile. The company plans to advance LYT-200 into a Phase 2 trial following a successful FDA meeting and Fast Track designation.

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-PRTCY
Sep 21, 2026
PRTCYPhases

PureTech Announces Successful End-of-Phase 1 Meeting with U.S. Food and Drug Administration (FDA) and Receipt of Fast Track Designation for LYT-200 in Relapsed/Refractory (R/R) High-Risk Myelodysplastic Syndromes (HR-MDS)

PureTech Health announced a successful End-of-Phase 1 meeting with the FDA and received Fast Track designation for LYT-200, aimed at treating relapsed/refractory high-risk myelodysplastic syndromes. The upcoming Phase 2 STRIDE-MDS trial will evaluate LYT-200's efficacy in approximately 125 patients. Positive results from the Phase 1b trial support this advancement.

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About PureTech Health plc

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