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Nintedanib

Phase 1

Drug Interactions | Small molecule | Other |PureTech Health plc|Last Updated: Jan 8, 2026

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

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Clinical trial landscape

Nintedanib · 1 trial · 1 indication

Phase 1 1
NCT06717100Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and NintedanibDrug Interactions
COMPLETED24 Analytics
PHASE1COMPLETED
Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and Nintedanib
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Study Design & Arms

Interventions

NameTypeDescription
Nintedanib 150 MG [Ofev]DRUGNintedanib 150 MG will be administered every 12 hours from Days 1 to 20. LYT-100 will be titrated from 275 MG three times a day on Days 8 to 10, to 550 MG three times a day on Days 11 to 13, to 825 MG three times a day on Days 14 to 30.
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Frequently asked questions about Nintedanib

What is Nintedanib used for in Drug Interactions?

Nintedanib is a small molecule being studied in the context of drug interactions. A completed Phase 1 trial evaluated the potential for drug-drug interactions when co-administering deupirfenidone (LYT-100) and nintedanib. The trial enrolled 24 participants and focused on the condition of drug interactions.

Who makes Nintedanib?

Nintedanib is being developed by PureTech Health plc, which trades under the ticker PRTC. The company is conducting clinical research on this small molecule, including a Phase 1 study to assess its interactions with other drugs.

What phase is Nintedanib in?

Nintedanib is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. One Phase 1 trial has been completed, with no active trials currently listed.

What clinical trials is Nintedanib in?

Nintedanib has one completed clinical trial, identified as NCT06717100. This Phase 1 study was designed to determine the potential for drug-drug interactions when co-administering deupirfenidone (LYT-100) and nintedanib. The trial enrolled 24 participants and was not randomized or double-blinded.

Is Nintedanib the same as deupirfenidone?

No, Nintedanib is not the same as deupirfenidone. They are distinct drugs that were studied together in a clinical trial to assess potential drug-drug interactions. The trial, NCT06717100, evaluated the effects of co-administering these two medications.