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pseudoephedrine

Phase 3

Nasal Congestion Associated With the Common Cold | Small molecule | ENT |Perrigo Company plc|Last Updated: Apr 22, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment565
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01744106A Multicenter Study of Pseudoephedrine for the Temporary Relief of Nasal Congestion in Children With the Common ColdPHASE3 COMPLETED 565Nov 1, 2012Apr 1, 2016Apr 22, 201611 United States
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Study Endpoints
Primary Endpoints
Nasal Congestion Severity (NCSi) (instantaneous) scores
1 Day

Weighted sum of change from baseline in Nasal Congestion Severity (NCSi) (instantaneous) scores over the first eight hours of treatment on Day 1

Secondary Endpoints
change from baseline in NCSi scores from 0 to 4 hours
Day 1
change from baseline in NCSi scores from 6, 7, and 8 hours
Day 1
Nasal Congestion Relief (NCR) reflective scores at 4 hours and 8 hours
Day 1
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
pseudoephedrine hydrochloride 30 mg tabletsEXPERIMENTALTest product
placebo tabletsPLACEBO_COMPARATORPlacebo
Interventions
NameTypeDescription
pseudoephedrine hydrochloride 30 mg tabletsDRUG -
Placebo tabletsDRUG -
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Eligibility Criteria
Age Range6 Years — 11 Years
SexALL
Healthy VolunteersNo
Study Sites11

Inclusion Criteria: 1. Male or female subjects, ages 6 through 11 years, are experiencing the common cold, but are otherwise healthy. 2. Subjects have an onset of cold symptoms within the past 2.5 days before screening and are experiencing self-reported nasal congestion of at least stuffy severity ...

Countries:United States
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