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Pfizer, Inc.

PFEFDA catalysts, PDUFA dates & pipeline intelligence
$29.79
▼ -0.27 · -0.89%

Financials

Last updated
Revenue
R&D Expenses
Operating CF
Total Assets
Total Liabilities
Equity
Shares Out.
D/E Ratio
Quarterly Cash
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52W LOW $23.6252W HIGH $30.44
Volume
25.30 M
Value Traded
1.34 B
Short % Float
2.64%
Days to Cover
4.4
+1.19%Week
+3.73%1 Month
+20.75%3 Month
+11.2%6 Month
-35.59%5 Year
+5,929.79%All Time

Cash Data

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  • SEC Filing

Key Stats

Market Cap
169.79 B
EPS (TTM)
0.76
P/E Ratio
39.19
Ent. Value
221.22 B
Total Shares
5.70 B
Float Shares
5.69 B
Insiders
0.09%
Institutions
69.71%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 2 data presentation
tivunatamig (PF-08634404, PF’4404)
first-line PD-L1-expressing non-small cell lung cancer (NSCLC) in combination with chemotherapy
Phase 2BiologicsOncology
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

PFE Catalyst Timeline

Dated clinical, regulatory and corporate events for Pfizer, Inc.

Catalyst Timeline

Dated clinical, regulatory & corporate events for Pfizer, Inc.

441Total events
39Upcoming
191Tier-1 (high impact)
2014 to 2031Coverage

Upcoming catalysts 2

T1PDUFA Date
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TALZENNAApproved
T3Poster Presentation
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tivunatamig

Event history 50

▲Oral PresentationPF-07872412Presentation
Detailed Phase 2 results for 25vPnC presented orally at IDWeek 2026
invasive pneumococcal disease (IPD) preventionsource ↗
▲Full ResultsPF-07872412Clinical Data
Detailed Phase 2 immunogenicity/safety results across 25 serotypes for 25vPnC
invasive pneumococcal disease (IPD) preventionsource ↗
▲Partnership / LicenseCorporate
Enodia enters research collaboration and license agreement with Pfizer for Sec61 inhibitors
▲FDA ApprovalTUKYSAApprovedFDA Decision
FDA approves TUKYSA with trastuzumab and pertuzumab as front-line maintenance for HER2+ metastatic breast cancer
HER2+ metastatic breast cancer (front-line maintenance)source ↗
▲Corporate ApprovalCorporate
Pfizer board declares fourth-quarter 2026 dividend of $0.43 per share
▲Topline ReadoutRitlecitinibApprovedClinical Data
LITFULO 100 mg met co-primary endpoints in TRANQUILLO 2 at Week 52
nonsegmental vitiligosource ↗
▲Oral PresentationRitlecitinibApprovedPresentation
Late-breaking oral presentation of TRANQUILLO 2 and TRANQUILLO results at EADV 2026
nonsegmental vitiligosource ↗
●Additional DataCibinqoApprovedClinical Data
Late-breaking exploratory serum protein biomarker analysis from JADE COMPARE
atopic dermatitissource ↗
●Safety Data UpdateCibinqoApprovedClinical Data
Final integrated safety analysis of CIBINQO in 3,850 patients with up to 6.5 years exposure
atopic dermatitissource ↗
▲Primary Endpoint MetRitlecitinibApprovedClinical Data
TRANQUILLO 2 co-primary endpoints met
nonsegmental vitiligosource ↗
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Every PDUFA date, readout, approval and corporate move, tiered by market impact and updated daily.
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Past FDA Catalysts and PDUFA Decisions

How PFE actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-10-26TALZENNA plus XTANDI (talazoparib + enzalutamide) PDUFA Date ApprovedPDUFA
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
113
Drugs Scored
rNPV / MCap
Top Drug
Top 1%
Large Pharma
(rank 1 of 657)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Jun 2026; product lines: last four quarters to Jun 2026 (10-K and 10-Q))
ProductRevenuePrior periodChange
Eliquis
Vyndaqel
Prevnar family
Ibrance
Comirnaty
Padcev
Xtandi
Paxlovid, EUA-Labeled
Nurtec ODT/Vydura
Lorbrena
Abrysvo
Xeljanz
Top 12 of 30 product lines shown.
Showing 96 of 1367 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
ibuzatrelvir Small moleculeNCT06679140COVID-19 SARS-CoV-2 InfectionPhase 3 RECRUITING 2,330Feb 12, 2028
ibuzatrelvir Small moleculeNCT07013474COVID-19 InfectionPhase 3 RECRUITING 300Feb 5, 2028
tilrekimig and rHuPH20 Small moleculeNCT07765888Atopic DermatitisPhase 3 RECRUITING 1,750Jun 2, 2028
tilrekimig and rHuPH20 Small moleculeNCT07772921AsthmaPhase 3 RECRUITING 2,200Aug 24, 2029
tilrekimig and rHuPH20 Small moleculeNCT07839884Moderate to Severe Chronic Obstructive Pulmonary DiseasePhase 3 NOT YET_RECRUITING 1,360May 12, 2034
PF-07275315 Small moleculeNCT05995964Atopic DermatitisPhase 2 ACTIVE NOT_RECRUITING 507Apr 1, 2027
PF-07275315 Small moleculeNCT07363694Moderate to Severe Chronic Obstructive Pulmonary DiseasePhase 2 RECRUITING 1,156Jan 16, 2031
PF-07275315 Small moleculeNCT06977581AsthmaPhase 2 RECRUITING 252May 31, 2027
Fidanacogene elaparvovec Gene therapyNCT03861273Hemophilia BPhase 3 ACTIVE NOT_RECRUITING 51Feb 25, 2028
sigvotatug vedotin ADCNCT06758401Non-Small Cell Lung CancerPhase 3 RECRUITING 714Mar 1, 2029
sigvotatug vedotin ADCNCT06012435Carcinoma, Non-Small Cell LungPhase 3 ACTIVE NOT_RECRUITING 1,774May 17, 2028
PF-08634404 Monoclonal antibodyNCT07222566Advanced Non-Small Cell Lung CancerPhase 3 RECRUITING 1,410Aug 26, 2032
PF-08634404 Monoclonal antibodyNCT07578649Endometrial NeoplasmsPhase 3 NOT YET_RECRUITING 600Jan 30, 2031
PF-08634404 Small moleculeNCT07222800Intestinal NeoplasmsPhase 3 RECRUITING 800Aug 17, 2031
PF-08634404 Monoclonal antibodyNCT07392892Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal AdenocarcinomaPhase 2 RECRUITING 840Jul 21, 2032
PF-08634404 Small moleculeNCT07226999Small Cell Lung CancerPhase 2 RECRUITING 590Mar 11, 2034
PF-08634404 Monoclonal antibodyNCT07489066CarcinomaPhase 2 RECRUITING 120Jul 30, 2031
PF-08634404 Monoclonal antibodyNCT07227298Advanced/Metastatic Non-Small Cell Lung CancerPhase 1 RECRUITING 162Aug 23, 2033
PF-08634404 Monoclonal antibodyNCT07227012Carcinoma, HepatocellularPhase 1 RECRUITING 138Oct 17, 2028
PF-08634404 Monoclonal antibodyNCT07421700Urothelial CancerPhase 1 RECRUITING 132Sep 25, 2028
PF-08634404 Small moleculeNCT07227415Carcinoma, Renal CellPhase 1 RECRUITING 224Nov 1, 2028
PF-08046054 Small moleculeNCT07144280Non-small Cell CarcinomaPhase 3 RECRUITING 680Mar 10, 2032
PF-08046054 Small moleculeNCT05208762Carcinoma, Non-Small-Cell LungPhase 1 RECRUITING 714Jan 4, 2029
PF-07220060 Small moleculeNCT07890597Early Breast CancerPhase 3 NOT YET_RECRUITING 3,800Aug 20, 2042
PF-07220060 Small moleculeNCT05262400Breast CancerPhase 3 ACTIVE NOT_RECRUITING 1,391Feb 26, 2027
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PTRS, rNPV, enrollment velocity, trial design quality and ML risk signals for every asset above.
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Clinical Trial Results

Readouts, endpoints and source filings for every PFE program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
PF-07872412 pneumococcal diseasePhase 22026-10-24strong immune responses across all 25 serotypes in infantsRead MorePfizer's 25-Valent Pediatric Pneumococcal Conjugate Vaccine Candidate Shows Robust Phase 2 Data at IDWeek 2026Read More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
BOURLA ALBERTDirector, Officer (Chairman & CEO)Buy 38,000 429,173 held$26.34 08/12/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
PROSIGHT MANAGEMENT, LP 0.6 % (-64.7 %) 3.26 M 135.37 K -37.04% ( -79.63 K)
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Shares held by hedge funds each quarter, and who bought or sold.

PFE Institutional Ownership Trends

PFE Short Interest

Shares sold short, counted twice a month.

2.64%
Short % of Float
of tradable shares sold short
150.2M
Shares Sold Short
-3.2% vs prior count
4.4 Moderate
Days to Cover
trading days of normal volume to buy every short share back
34.0M
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-10-30
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Per-expiry call and put volume, open interest, put-call ratios and implied volatility.
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

CallsPutsLog scale
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Competitive positioning

How PFE ranks across every disease it competes in

Competitive Position is a premium feature
See how PFE ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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PFE News

PFE
Oct 26, 2026
PFEFDA Updates
▼ -0.9%today

Pfizer’s TALZENNA Plus XTANDI FDA-Approved for an Earlier Metastatic Prostate Cancer Treatment Setting

Pfizer announced FDA approval for TALZENNA in combination with XTANDI for treating men with HRR gene-mutated metastatic prostate cancer. This approval is based on Phase 3 TALAPRO-3 data, demonstrating a 52% reduction in the risk of radiographic progression or death. The combination therapy is now available earlier in the treatment course, potentially benefiting more patients.

Read more →
PFE
Oct 24, 2026
PFEPhases
▼ -0.9%today

Pfizer's 25-Valent Pediatric Pneumococcal Conjugate Vaccine Candidate Shows Robust Phase 2 Data at IDWeek 2026

Pfizer's investigational 25-valent pneumococcal conjugate vaccine, PF-07872412, demonstrated strong immune responses in infants during a Phase 2 study. The vaccine showed safety comparable to PREVNAR 20 and elicited robust responses against all 25 serotypes, including five new ones. These results support ongoing Phase 3 trials aimed at enhancing protection against invasive pneumococcal disease in children.

Read more →
PFE
Oct 14, 2026
PFEConferences/Events

Pfizer Showcases Clinical Advancements Across Infectious Diseases at IDWeek 2026

Pfizer will present data from over 50 research abstracts at IDWeek 2026, focusing on advancements in infectious disease vaccines, including pneumococcal and Lyme disease vaccines. Key highlights include promising results from Phase 2 and Phase 3 studies on next-generation vaccines. The company emphasizes its commitment to addressing urgent public health challenges through innovative vaccine development.

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PFE
Oct 13, 2026
PFEGeneral

Enodia Therapeutics Announces Research Collaboration and License Agreement with Pfizer to Develop Sec61-Targeting Small Molecules

Enodia Therapeutics has entered a research collaboration and license agreement with Pfizer to develop Sec61 inhibitors. This partnership aims to leverage Enodia's proprietary platform for discovering small-molecule therapeutics that inhibit disease-driving proteins while preserving essential functions. Enodia will handle discovery activities, with Pfizer taking over clinical and commercial responsibilities post-collaboration. The agreement could be worth over $500 million.

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PFE
Oct 7, 2026
PFEFDA Updates

Pfizer’s TUKYSA Regimen Receives FDA Approval as Front-Line Maintenance Treatment for HER2+ Metastatic Breast Cancer

Pfizer has received FDA approval for TUKYSA (tucatinib) in combination with trastuzumab and pertuzumab. This approval allows the drug to be used as a maintenance treatment for adults with unresectable locally advanced or metastatic HER2+ breast cancer following induction therapy. This marks a significant advancement in treatment options for patients at an earlier stage of metastatic disease.

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PFE
Oct 6, 2026
PFEGeneral

Pfizer Declares Fourth-Quarter 2026 Dividend

Pfizer Inc. has declared a $0.43 dividend for the fourth quarter of 2026, payable on December 7, 2026. This decision reflects the company's ongoing commitment to its capital allocation strategy, aiming to maintain and grow dividends over time. The upcoming dividend will be the 352nd consecutive payment to shareholders.

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PFE
Oct 2, 2026
PFEPhases

Pfizer’s LITFULO Significantly Improved Facial and Total Body Repigmentation in Patients with Nonsegmental Vitiligo

Pfizer Inc. presented positive results from two Phase 3 trials for LITFULO (ritlecitinib), demonstrating significant improvements in facial and total body repigmentation in patients with nonsegmental vitiligo. The trials, TRANQUILLO 2 and TRANQUILLO, showed that both 100 mg and 50 mg dosages outperformed placebo. Patient-reported outcomes further supported these findings, indicating reduced disease severity.

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PFE
Oct 1, 2026
PFEPhases

Pfizer's Tilrekimig Shows Significant Skin Clearance in Phase 2 Atopic Dermatitis Study

Pfizer presented positive results from a Phase 2 study of tilrekimig for atopic dermatitis. The study achieved its primary endpoint, showing a significant increase in skin clearance among participants. This was measured by the Eczema Area and Severity Index at Week 16, indicating promising efficacy for the treatment.

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PFE
Sep 29, 2026
PFEGeneral

Professor Bill Sessa, Former Chief Scientific Officer of Internal Medicine at Pfizer, Appointed Chair of Isomab's Scientific Advisory Board

Isomab Ltd has appointed Professor Bill Sessa as Chair of its Scientific Advisory Board. He will lead a team of distinguished vascular biologists as the company advances its first-in-class anti-VEGF-A165b antibody, ISM-001, towards clinical trials for chronic angina. This strategic move aims to enhance the development of novel therapies for patients with cardiovascular diseases.

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PFE
Sep 28, 2026
PFEConferences/Events

Pfizer Advances Today’s Cancer Care and Tomorrow's Potential Breakthroughs at ESMO

Pfizer Inc. will present 45 research abstracts at the upcoming ESMO Congress in Madrid. The presentations will include 11 oral presentations highlighting advancements in cancer treatments, particularly in breast, genitourinary, and lung cancers. This event underscores Pfizer's commitment to enhancing cancer care and exploring future breakthroughs.

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PFE
Sep 22, 2026
PFEConferences/Events

Pfizer Invites Public to View and Listen to Webcast of November 3 Conference Call with Analysts

Pfizer Inc. has announced a conference call scheduled for November 3, 2026, at 10:00 a.m. EST. The call aims to update investors on the company's third quarter performance. Participants can access the webcast and the performance report through Pfizer's investor website.

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PFE
Sep 17, 2026
PFEFDA Updates

Health Canada Authorizes Pfizer and BioNTech's Omicron XFG-Adapted COVID-19 Vaccine

Health Canada has authorized Pfizer and BioNTech's updated COMIRNATY vaccine for the 2026-2027 season, specifically targeting the Omicron XFG variant. This approval is based on extensive clinical and real-world data demonstrating the vaccine's safety and effectiveness. The vaccine will be available through various channels, ensuring equitable access across Canada.

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PFE
Sep 15, 2026
PFEConferences/Events

Pfizer Invites Public to Listen to Webcast of Pfizer Discussion at Healthcare Conference

Pfizer Inc. is inviting the public and investors to listen to a webcast featuring Alexandre de Germay, the Chief International Commercial Officer, at the J.P. Morgan U.S. All Stars 2026 Conference. The event is scheduled for September 22, 2026, at 11:50 a.m. BST. Details for accessing the webcast can be found on Pfizer's investor website.

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PFE
Aug 27, 2026
PFEFDA Updates

Pfizer and BioNTech Receive U.S. FDA Approval for XFG-adapted COVID-19 Vaccine

Pfizer and BioNTech have received FDA approval for their 2026-2027 COVID-19 vaccine, which targets the XFG variant. The vaccine is intended for adults aged 65 and older, as well as younger individuals with underlying health conditions. Shipping of the vaccine will commence immediately to ensure timely access. The approval is based on comprehensive data demonstrating the vaccine's effectiveness against various SARS-CoV-2 variants.

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PFE
Aug 18, 2026
PFEGeneral

Legal Bay Pre-Settlement Funding Reports Pfizer Agrees to Settle Depo-Provera Birth Control Litigation

Pfizer has agreed to a settlement program to resolve a substantial number of lawsuits alleging that Depo-Provera caused intracranial meningiomas. Legal Bay estimates that around 5,000 claims could settle for over $1.2 billion. The financial terms remain confidential, and actual compensation will depend on various factors. The settlement is seen as a significant development for affected claimants.

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PFE
Aug 14, 2026
PFEFDA Updates

Pfizer and Valneva’s Lyme Disease Vaccine Candidate Marketing Authorization Application Validated by European Medicines Agency

Pfizer and Valneva announced that the European Medicines Agency has validated their Marketing Authorization Application for PF-07307405, a Lyme disease vaccine candidate. This application is based on positive results from the Phase 3 VALOR trial, which demonstrated over 70% efficacy. The vaccine was well tolerated, with no safety issues reported, marking a significant step in addressing Lyme disease in Europe.

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PFE
Aug 4, 2026
PFEGeneral

Pfizer Reports Second-Quarter Results And Raises Midpoint of 2026 Revenue Guidance

Pfizer Inc. reported its second-quarter financial results for 2026, showcasing a strong performance. The company raised its full-year revenue guidance by $500 million at the midpoint while reaffirming its adjusted diluted EPS guidance. CEO Dr. Albert Bourla highlighted the company's commitment to delivering on financial expectations.

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PFE
Jul 30, 2026
PFEPhases

Pfizer Announces Positive Topline Phase 3 Results for LITFULO in Patients with Nonsegmental Vitiligo

Pfizer has reported positive topline results from two Phase 3 trials of LITFULO for treating nonsegmental vitiligo. The trials assessed the drug's efficacy and safety in patients with varying disease severity. Both studies showed significant results for the 50 and 100 milligram doses, indicating a promising treatment option.

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About Pfizer, Inc.

New York, NY 75,000 employees pfizer.com
Headquarters66 HUDSON BOULEVARD EAST, NEW YORK, NY, 10001-2192
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