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etynodiol diacetate

Phase 1

Therapeutic Equivalency | Small molecule | Other |Pfizer, Inc.|Last Updated: Apr 4, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment20
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01359163A Study To Determine Bioequivalence Between The Commercial Femulen Tablets And A Reformulation Of Femulen Tablets In Healthy Female SubjectsPHASE1 COMPLETED 20Jun 1, 2011Jul 1, 2011Apr 4, 20121 Singapore
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Study Endpoints
Primary Endpoints
Area under the curve to last time point observed (AUCt)
0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48
Highest concentration (Cmax)
0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48
Secondary Endpoints
Area under the curve to infinity (AUCinf)
0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48
Area under the curve percent to infinity (AUC%inf)
0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48
Half-life (T1/2)
0.5, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Femulen commercial tabletsACTIVE_COMPARATOR -
Femulen reformulated tabletsEXPERIMENTAL -
Interventions
NameTypeDescription
etynodiol diacetateDRUGtablet, 0.5 mg, single dose
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Eligibility Criteria
Age Range21 Years — 55 Years
SexFEMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>45 kg (99 lbs). * Healthy female subjects between the ages of 21 and 55 years, inclusive. Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical e...

Countries:Singapore
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