Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
bosutinib or bosutinib+ aprepitant · 1 trial · 1 indication
AUC is a measure of the plasma concentration of the drug over time. It is used to characterize drug absorption.
Cmax is the peak concentration.
| Arm | Type | Description |
|---|---|---|
| Healthy volunteers | OTHER | Healthy volunteers taking a single dose of bosutinib and a single dose of bosutinib plus aprepitant in random order |
| Name | Type | Description |
|---|---|---|
| bosutinib or bosutinib + aprepitant | DRUG | Single dose of bosutinib (500 mg) or single dose of bosutinib (500 mg) and aprepitant (125 mg) |
Inclusion Criteria: * Healthy male and/or female subjects with an informed consent document signed and dated by the subject. Exclusion Criteria: * Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neur...